NFL Week 6 Opening Odds, Betting Lines, and spreads: Fade the fading Panthers

Carolina Panthers wide receiver Adam Thielen (19) celebrates with quarterback Bryce Young (9) after scoring a touchdown in the first quarter at Bank of America Stadium.
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Caleb Wilfinger


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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email

Heading into NFL Week 6, only two teams remain without a loss. The undefeated teams are the San Francisco 49ers and the Philadelphia Eagles, as these squads seemed determined to set up a rematch of last year’s NFC Championship game next January.

With most sportsbooks having released their lines for the next week on Sunday night, here are the opening Week 6 lines. Make sure you keep checking our NFL predictions as we add our picks on the side and total for every game throughout the week. Our experts have been red hot, cashing on multiple parlays and boasting a 4-0 NFL best bets record in Week 5 to improve to a 14-3 run!

NFL Week 5 opening lines and odds

Odds available at FanDuel Sportsbook at time of publishing.

Denver Broncos +10.5 (-105) vs Kansas City Chiefs -10.5 (-115) – Thursday Night Football
Baltimore Ravens -4 (-110) vs Tennessee Titans +4 (-110)
Carolina Panthers +14 (-110) vs Miami Dolphins -14 (-110)
Detroit Lions -3 (-120) vs Tampa Bay Buccaneers (+100)
Seattle Seahawks +3 (-120) vs Cincinnati Bengals -3 (+100)
San Francisco 49ers -3.5 (-110) vs Cleveland Browns +3.5 (-110)
Washington Commanders +2.5 (-110) vs Atlanta Falcons -2.5 (-110)
Minnesota Vikings -3 (-120) vs Chicago Bears +3 (+100)
Indianapolis Colts +4.5 (-110) vs Jacksonville Jaguars -4.5 (-110)
New Orleans Saints -2.5 (-110) vs Houston Texans +2.5 (-110)
New England Patriots +2.5 (-105) vs Las Vegas Raiders -2.5 (-115)
Arizona Cardinals +6 (-110) vs Los Angeles Rams -6 (-110)
Philadelphia Eagles -6 (-110) vs New York Jets +6 (-110)

New York Giants +14 (-105) vs Buffalo Bills -14 (-115) – Sunday Night Football
Dallas Cowboys -2.5 (-110) vs Los Angeles Chargers +2.5 (-110) – Monday Night Football

Best early bet for NFL Week 6: Miami Dolphins -14 over Carolina Panthers (-110)

It’s never fun laying 2 touchdowns in the NFL but I think we’ve got a spot to keep fading what I believe to be one of the worst teams in football. The Dolphins are going to be an extremely public side this week, but there is no reason to back a Panthers team that has massive holes on defense and is going up against the best offense in the NFL this season. Carolina was just shredded in Detroit and the team speed of Miami will be a major step up from what the Panthers just saw with the Lions. Furthermore, the Dolphins will get to stay at home following a comfortable 31-16 victory over the Giants in which the Dolphins didn’t even play all that well for long stretches of the game. There will be sharper sides to monitor this week, but I’d still grab the Dolphins at 2 touchdowns or better.

We’ll have NFL Week 6 picks for every game so make sure you keep checking back!

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