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NFL Week 7 picks and predictions - Millionaire maker 12-team money line parlay at +45344 odds: Lions roar on the road

NFL Week 7 picks and predictions - Millionaire maker 12-team money line parlay at +45344 odds: Lions roar on the road

Phil Agius
Phil AgiusAuthor
UpdatedSep 15, 2026
Reading time5 min

The chances of making a million by picking every game on the Sunday and Monday slates are greatly improved as 6 teams being on a bye week means we merely need to predict the outcomes of 12 games correctly to hit the jackpot in Week 7!

One of the most fun bets you can have with an NFL wager is to swing for the fences with a millionaire parlay, so I’ve taken a money line pick from every remaining game this week to create this parlay, which pays out at +45344 odds at DraftKings Sportsbook at the time of publishing. With no early London game this week, there are no excuses for not getting up early enough to lock in your bet!

Let’s see the teams that could make us rich across Sunday and Monday night. Make sure to also check out our NFL Week 7 picks for every matchup.

Detroit Lions over Baltimore Ravens (+124)

It shouldn’t really count as an upset pick when you’re taking the team with the joint-best record in the league, but the 5-1 Detroit Lions are underdogs for this tricky trip to the Baltimore Ravens. The Lions are an impressive 3-0 on the road, while the Ravens have already lost at home to Indianapolis, so let’s get this parlay started with a plus-money pick.

Check out all of our Lions vs Ravens predictions

Buffalo Bills over New England Patriots (-425)

The Bills labored to a win against the Giants last week but they did at least get the job done for bettors who had them as a money-line lock even though they let down their spread backers. The Patriots are 0-3 at home already and the Bills (the team) should beat Bill (the head coach) with few issues.

Check out all of our Bills vs Patriots predictions

Washington Commanders over New York Giants (-148)

The Commanders finally showed signs of being the defense they should be in last week’s win over the Falcons. If they had lost that game, both these teams would be on 4-game losing streaks coming into this contest, but as it is, the relatively red-hot Commanders are in position to destroy what’s left of the Giants’ injury-hit offensive line.

Check out all of our Commanders vs Giants predictions

Atlanta Falcons over Tampa Bay Buccaneers (+120)

This is a game that many people might wisely choose to leave out of their parlays this weekend, as neither of these NFC South teams is particularly trustworthy, but as it’s a close matchup, we’ll roll with the underdog.

Check out all of our Falcons vs Buccaneers predictions

Cleveland Browns over Indianapolis Colts (-148)

The Browns will have taken down thousands of parlays last week with their upset win of the unbeaten 49ers behind practice-squad QB PJ Walker. They switch to the role of favorite this week, potentially with Deshaun Watson back in the team and boasting the league’s #1 defense. That should make life tough for the Colts.

Check out all of our Browns vs Colts predictions

Las Vegas Raiders over Chicago Bears (-135)

This should be a battle of backup quarterbacks as either Aidan O’Connell or Brian Hoyer will lead the Raiders, probably against undrafted rookie Tyson Bagent of the Bears. The Raiders should have the edge there, whoever they opt for, and so we’re going to start this parlay with a 6th straight road team!

Seattle Seahawks over Arizona Cardinals (-395)

It’s time to switch to a home team and take the Seahawks with their big home-field advantage at Lumen Field. The Cardinals have had 3 straight wide-margin losses since their big, but solitary, win against Dallas.

Check out all of our Cardinals vs Seahawks predictions

Los Angeles Rams over Pittsburgh Steelers (-166)

The Rams have one of the best 3-3 records you could get with the losses having been to the 49ers, Bengals and Eagles, and they have been much stronger on the balance of their play than the Steelers, even though Pittsburgh has a winning record at 3-2.

Check out all of our Steelers vs Rams predictions

Kansas City Chiefs over Los Angeles Chargers (-238)

It’s possible to see the Chargers making the most of their talent to look good in this AFC West showdown with the Chiefs, but it is harder to see them actually getting over the line and beating the Super Bowl champions.

Check out all of our Chargers vs Chiefs predictions

Green Bay Packers over Denver Broncos (-115)

This is one of the lower-confidence picks in this week’s list as the Packers have not looked great in their last 2 games. They do still have twice as many wins as the 1-5 Broncos, whose only success was against the Bears.

Check out all of our Packers vs Broncos predictions

Miami Dolphins over Philadelphia Eagles (+114)

We’re back to taking road teams at plus-money odds again in this collision of 5-1 teams on Sunday night. The Dolphins are in better shape injury-wise and could exploit an Eagles secondary that may be missing one or two key pieces.

Check out all of our Dolphins vs Eagles predictions

San Francisco 49ers over Minnesota Vikings (-305)

The 49ers had a lot of excuses for last week’s loss to the Browns, but the wind and rain that bothered QB Brock Purdy and kicker Jake Moody in Cleveland won’t be a problem in Minnesota’s dome. The 49ers should also find the Vikings’ defense a lot easier to dominate than the Browns’ top-ranked unit.

Check out all of our 49ers vs Vikings predictions

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