Opening college football betting lines, odds and spreads for Week 12 of the season

PAC 12 UCLA Bruins quarterback Dorian Thompson-Robinson drops back to pass against Colorado
Photo of Caleb Wilfinger

Caleb Wilfinger


Show Bio

Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email
Read more about Caleb Wilfinger

Week 11 of the college football season is in the books. In particular, Saturday delivered another eventful slate. We had close finishes, a few massive upsets and compelling games galore. In all, it was a weekend that further solidified the excitement this college football season.

Now it’s time to turn our attention to Week 12. This slate is another compelling one, with plenty of intriguing matchups. The opening lines were released at most sportsbooks on Sunday, so let’s take a look at these openers and give our first impressions.

Get our NCAAF picks for this week’s action

NCAAF Week 12 opening lines and odds

Odds available at DraftKings Sportsbook at time of publishing. 

  • Bowling Green +14.5 (-110) vs Toledo – Tuesday, November 15
  • Ohio -4 (-110) vs Ball State – Tuesday, November 15
  • Western Michigan +9.5 (-110) vs Central Michigan – Wednesday, November 16
  • Miami OH +3 (-110) vs Northern Illinois – Wednesday, November 16
  • SMU +2.5 (-110) vs Tulane – Thursday, November 17
  • San Diego State -13.5 (-110) vs New Mexico – Friday, November 18
  • Illinois +17 (-110) vs Michigan – Saturday, November 19
  • Texas -8.5 (-110) vs Kansas – Saturday, November 19
  • Tennessee -21 (-110) vs South Carolina – Saturday, November 19
  • Penn State -19 (-110) vs Rutgers – Saturday, November 19
  • Georgia -22.5 (-110) vs Kentucky – Saturday, November 19
  • Kansas State -7 (-110) vs West Virginia – Saturday, November 19
  • Texas Tech +2.5 (-110) vs Iowa State – Saturday, November 19
  • Western Kentucky +7 (-110) vs Auburn – Saturday, November 19
  • Ohio State -27 (-110) vs Maryland – Saturday, November 19
  • Ole Miss -2 (-110) vs Arkansas – Saturday, November 19
  • Miami FL +19 (-110) vs Clemson – Saturday, November 19
  • Indiana +12.5 (-110) vs Michigan State – Saturday, November 19
  • Iowa +3 (-110) vs Minnesota – Saturday, November 19
  • Syracuse +9.5 (-110) vs Wake Forest – Saturday, November 19
  • NC State +4 (-110) vs Louisville – Saturday, November 19
  • Washington State -3.5 (-110) vs Arizona – Saturday, November 19
  • Florida -14.5 (-110) vs Vanderbilt – Saturday, November 19
  • USC -3 (-110) vs UCLA – Saturday, November 19
  • Colorado +31.5 (-110) vs Washington – Saturday, November 19
  • TCU -2 (-110) vs Baylor – Saturday, November 19
  • Utah +3 (-110) vs Oregon – Saturday, November 19

We’ll have college football predictions for all of this week’s biggest games!

Best early bets for NCAAF Week 12

UCLA +3 (-110) vs USC

The lookahead line on this game was UCLA -1, which seemed perfectly priced given the strengths and weaknesses of these teams. However, it since moved to USC laying 3 points after the Bruins fell to Arizona on Saturday night. I’m not too concerned about the result. The Bruins were extremely flat for the first half and it was apparent that they were looking ahead to this massive showdown against their crosstown rivals. After all, Dorian Thompson-Robinson and this offense are still 6th in EPA per rush, while USC’s defense is 130th. The loss of Travis Dye is a massive blow for the USC rushing attack, as well. In a game where both offenses will hold considerable advantages over the opposing defenses, this should come down to the last possession. Take the points with the underdog.

Kansas +8.5 (-110) vs Texas

This is an extremely difficult spot for Texas to get up for. The Longhorns were just 7-point favorites in a primetime matchup against TCU at home. Texas came up woefully short in that game despite holding a number of statistical and talent advantages on paper. Now this Longhorns team doesn’t have much to play for with 4 losses already on the season and needing help from other teams to qualify for the Big 12 Championship game. On the other hand, Kansas is coming off a loss to Texas Tech in which it did just as much to lose that game as the Red Raiders did to win it. In a game that will mean a lot to the Jayhawks, I think anything over a touchdown is pretty appealing for a team that consistently shows up at home this season. Look for Kansas to keep things close.

Pickswise is the home of College Football Picks and College Football Predictions. Check out our latest College Football analysis including our College Football Parlay picks and our College Football Best Bets.

By signing up you agree to our terms and privacy policy