Opening college football betting lines, odds and spreads for Week 3 of the CFB season: Oklahoma to pile on Nebraska’s pain

Oklahoma coach Brent Venables shouts during the University of Oklahoma's annual spring football game at Gaylord Family-Oklahoma Memorial Stadium in Norman, Okla., Saturday, April 23, 2022.
Photo of Ricky Dimon

Ricky Dimon

NCAAF

Show Bio

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports--just about any and all you can think of!--and coaching tennis in Atlanta, Ga. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me.

Week 2 of the college football season was positively wild. In fact, the 2022 campaign as a whole has been the same, and we aren’t even a month into it. The Sun Belt Conference is making moves, Nebraska has already fired head coach Scott Frost and there has already been a change atop the AP rankings.

With big shoes to fill, what will Week 3 do for an encore? The opening lines were released at most sportsbooks on Sunday, so let’s take a look at them and offer our first impressions.

NCAAF Week 3 opening lines and odds

Odds available at DraftKings Sportsbook at time of publishing. 

  • Florida State -1.5 (-110) vs Syracuse – Friday, September 16
  • Air Force -14.5 (-110) vs Wyoming – Friday, September 16
  • Georgia -24.5 (-110) vs South Carolina – Saturday, September 17
  • UConn +46.5 (-110) vs Michigan – Saturday, September 17
  • Oklahoma -13.5 (-110) vs Nebraska – Saturday, September 17
  • Texas State +31 (-110) vs Baylor – Saturday, September 17
  • Purdue -1 (-110) vs Syracuse – Saturday, September 17
  • Cincinnati -20 (-110) vs Miami (OH) – Saturday, September 17
  • Western Kentucky +7 (-110) vs Indiana – Saturday, September 17
  • South Alabama -14 (-110) vs UCLA – Saturday, September 17
  • Ohio +21.5 (-110) vs Iowa State – Saturday, September 17
  • Rutgers -17 (-110) vs Temple – Saturday, September 17
  • Old Dominion +10.5 (-110) vs Temple – Saturday, September 17
  • California +12.5 (-110) vs Notre Dame – Saturday, September 17
  • Tulane +17 (-110) vs Kansas State – Saturday, September 17
  • BYU +3.5 (-110) vs Oregon – Saturday, September 17
  • Ole Miss -14.5 (-110) vs Georgia Tech – Saturday, September 17
  • Penn State -3 (-115) vs Auburn – Saturday, September 17
  • Vanderbilt +1.5 (-110) vs Northern Illinois – Saturday, September 17
  • Colorado +27.5 (-110) vs Minnesota – Saturday, September 17
  • Ohio +21.5 (-110) vs Iowa State – Saturday, September 17
  • New Mexico State +37.5 (-110) vs Wisconsin – Saturday, September 17
  • UL Monroe +49.5 (-110) vs Alabama – Saturday, September 17
  • Kansas +10 (-110) vs Houston – Saturday, September 17
  • Liberty +16.5 (-110) vs Wake Forest – Saturday, September 17
  • Colorado State +16.5 (-110) vs Washington State – Saturday, September 17
  • Mississippi State -2.5 (-110) vs LSU – Saturday, September 17
  • Toledo +31 (-115) vs Ohio State – Saturday, September 17
  • Akron +47.5 (-110) vs Tennessee – Saturday, September 17
  • Texas Tech +9.5 (-110) vs NC State – Saturday, September 17
  • Arkansas State +13 (-110) vs Memphis – Saturday, September 17
  • Michigan State +2 (-110) vs Washington – Saturday, September 17
  • South Florida +24.5 (-110) vs Florida – Saturday, September 17
  • Pittsburgh -10 (-110) vs Western Michigan – Saturday, September 17
  • Nevada +21 (-110) vs Iowa – Saturday, September 17
  • SMU +3 (-110) vs Maryland – Saturday, September 17
  • UCF -10 (-110) vs Florida Atlantic – Saturday, September 17
  • Louisiana Tech +32 (-110) vs Clemson – Saturday, September 17
  • UTSA +13.5 (-110) vs Texas – Saturday, September 17
  • Miami (FL) +6 (-110) vs Texas A&M – Saturday, September 17
  • San Diego State +21 (-110) vs Utah – Saturday, September 17
  • Fresno State +12.5 (-110) vs USC – Saturday, September 17
  • Eastern Michigan +19.5 (-110) vs Arizona State – Saturday, September 17

We’ll have college football picks and NCAAF predictions for almost every game this season!

Best early bets for NCAAF Week 3

Oklahoma -13.5 (-110) over Nebraska

Frost’s exit is probably addition by subtraction, but you can’t expect the Cornhuskers to turn things around right away — especially not when Oklahoma is next up on the schedule. Nebraska is terrible. Just when you thought it couldn’t get any worse than flying a third of the way around the world to get beat by Northwestern, the ‘Huskers lost at home to Georgia Southern. In this 4-team playoff era when style points can matter, don’t think for a second that the Sooners are going to take it easy on a former conference rival.

USC -12.5 (-115) over Fresno State

USC is going to have to do more than beat Rice and Stanford for me to entirely jump on the bandwagon, but early returns on the head coach Lincoln Riley era with Caleb Williams at quarterback are encouraging. Fresno State just gave up 35 points in a loss to Oregon State, so there is no reason to think it can contain Williams. Get the line now while it’s below the key numbers of 13 and 14.

Miami (FL) +6 (-110) vs Texas A&M

Texas A&M head coach Jimbo Fisher can give all the pep talks he wants, but a home loss to Appalachian State is one from which you don’t easily recover. Unless the Aggies somehow win on the road at Alabama next month (year right!), for all intents and purposes their College Football Playoff hopes are over. The Hurricanes, who have blown out 2 unspectacular opponents, are more than capable of adding insult to injury.

At Pickswise we offer free expert College Football Picks an College Football Predictions for all games in the Power Five conferences and the top 25 teams outside of Power five, including our College Football Parlay picks each week.

Virginia Bonuses

See All
Unibet

$100

Get a $100 Risk-Free Bet!

Register for a new Unibet account & make a deposit

Place your first bet up to $100 risk-free!

Get refunded up if you lose up to $100

New players only. Terms & conditions apply. 21+. VA only.

BetRivers

$500

Get a $500 Risk-Free Bet on Colts vs. Broncos!

Sign up for a new BetRivers account using promo code PICKSWISE

Make your first deposit & get up to $500 in free bets

To get $500 in free bets, wager $500

Must be 21+. Play in IA Only. Gambling Problem? Call 1-800-BETS OFF

FanDuel Sportsbook

$1,000

Get a $1,000 No Sweat First Bet on Colts vs. Broncos

Sign up for a new FanDuel Sportsbook account and make your first deposit of $10+

Place your first bet up to $1,000!

Get refunded up if you lose up to $1,000

Must be 21+. First online real money wager only. $10 first deposit required. Bonus issued as non-withdrawable free bets that expire 14 days after receipt. See full terms at fanduel.com/sportsbook.

DraftKings

$200

Bet $5+ on Colts or Broncos ML, Get $200 If Your Team Wins

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Bet $5+ on the pre-game ML in any sport

Win $200 if your team wins

Offer valid for new players only. Must be 21 years or older to play. Reward paid in site credit. Full terms available at DraftKings Sportsbook.

PointsBet

$800

Get 4x $200 In Free Bets on Colts vs. Broncos

Sign up for a new PointsBet account

Bet up to $200 and If you lose, you get a refund

You will receive Free Bet(s) in the amount of the losing wager(s), up to $200 each for four days.

Must be 21+. Full terms are available at PointsBet.

Caesars Sportsbook

$1,250

Get a $1,250 risk-free bet on Colts vs. Broncos

Sign up for a new Caesars Sportsbook account

Place your first bet of $10 or more

If your first bet loses, you’ll receive a refund up to $1,250 from Caesars in free bets

21+. Terms and conditions apply.

BetMGM

$1,000

Get a $1,000 Risk Free Bet on Colts vs. Broncos

Register for a new BetMGM & deposit

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

21+. Terms & conditions apply.

DraftKings

$100

Bet $5+ on MLB and get $100 in Free Bets Instantly!

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Bet $5+ on any MLB team to win their next game

Win $100 no matter what!

Offer valid for new players only. Must be 21 years or older to play. Reward paid in site credit. Full terms available at DraftKings Sportsbook.

PointsBet

$500

Get 5x $100 in Free Bets on Colts vs. Broncos

Sign up for a new PointsBet account

Make a bet of up to $100 and receive a refund if you lose

Get this offer once a day for the first 5 days you sign up

Must be 21+. Full terms are available at PointsBet.

DraftKings

$1,000

Get a $1,000 Deposit Bonus!

Register for a new DraftKings Sportsbook account & deposit

DraftKings will match 20% of your deposit up to $1,000 total

To get a $100 bonus, deposit $500

21+. Terms & conditions apply.

PointsBet

$2,000

Get $2,000 in Free Bets on Colts vs. Broncos

Register for a new PointsBet account & deposit

Receive a free bet refund up to $500 if your first fixed odds bet loses

& a free bet refund up to $1,500 if your first two PointsBetting Wager loses

Must be 21+. Full terms are available at PointsBet.

Monkey Knife Fight

$100

Claim Instant Deposit Match up to $100 + Free $5 game

Register for a Monkey Knife Fight account & deposit using promo code PICKSWISE100

Monkey Knife Fight will match your first deposit up to $100

Deposit $100 and you'll get $100 bonus + a free $5 game

18+. Terms and conditions apply. You must live in one of the states where real money DFS is legal.

TVG

$200

Get Your First Single-Horse Win Wager Back Up to $200 if you don't win

Register for a new TVG account and make a deposit

Place your first single horse win-type bet up to $200

If your horse doesn't win you'll get a refund up to $300

21+. T&C's apply. Please gamble responsibly.

TwinSpires

$200

Get a $200 Sign-Up Bonus with Twinspires Racebook!

Open your TwinSpires.com account using offer code BET200

$200 bonus cash will be credited in increments of $100 for every $400 wagered

To earn the full $200 bonus players must wager $800 within 30 days

21+. Terms and conditions apply.

Underdog Fantasy

$100

First deposit is 100% matched up to $100 with Underdog Fantasy

Sign up for a new account with Underdog Fantasy

Make your first deposit

Every dollar (up to $100) will be matched! Deposit $25, get $50; deposit $100, get $200, etc

Must be 21+ to play. Terms & conditions apply