Wise n' Shine: MLB picks, NFL odds and college football predictions for Friday, September 16

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Phil Agius


Show Bio

I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email contact@pickswise.com.
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Good morning, Pickswise Nation. The Chiefs and Chargers served up a close contest as expected last night, with Los Angeles getting a backdoor cover in a 3-point loss but at the expense of quarterback Justin Herbert sustaining a rib injury. We have another action-packed Friday of sports ahead with a big baseball slate, college football games, LIV golf and EPL soccer action. Let’s get straight to making your next bet better!

About Last Night

Chiefs beat Chargers, Herbert hurt
Pickswise cashed our picks for the side and total on Thursday Night Football, taking Chargers +4.5 and under 54 points as the Chiefs beat the Chargers 27-24. Our expert Clevta also had under 27 in the first half as his 3-star Best Bet. The biggest play of the game was a 99-yard pick-6 for Kansas City rookie Jaylen Watson after the Chargers had looked the better team in the first half. The worry for the Chargers was a rib injury sustained by QB Justin Herbert, with the team waiting on an assessment of the problem today. FanDuel Sportsbook has the 2-0 Chiefs at +700 odds for the Super Bowl behind only +500 Buffalo, with the 1-1 Chargers at +1600. The Chiefs are -105 odds for the AFC West with the Chargers at +260.

MLB Best Bet is a winner
Our only 3-star MLB play on Thursday of the Twins ML vs the Royals cashed as Minnesota won 3-2. The White Sox beat the Guardians 8-2 to make the AL Central even more interesting, while the Rays closed to within 1 win of the Blue Jays by beating them 11-0. There were a couple of late upsets, with the Reds beating the Cardinals 3-2 and the Diamondbacks shutting out the Padres 4-0.

Today’s Slate

Busy night of baseball
We have a full 15-game MLB slate today, including an afternoon contest between the Rockies and Cubs at 2:20 pm ET. The evening slate includes Orioles vs Blue Jays at 7:07 pm ET and Dodgers vs Giants at 10:15 pm ET on Apple TV+, plus Pirates vs Mets on ESPN+ at 7:10 pm ET. Read today’s MLB predictions.

College football Week 3 begins
The vast majority of the college football Week 3 action is tomorrow but there are games tonight including Florida State vs Louisville on ESPN at 7:30 pm ET and Air Force vs Wyoming on CBSSN at 8:00 pm ET. Read today’s NCAAF predictions.

EPL weekend slate begins
There are 7 EPL games on a reduced slate this weekend, with 2 games tonight and you can check out all our EPL picks. Our golf expert Diane Knox Balas also has LIV golf best bets for this weekend’s tournament in Chicago.

Best Bet of the Day

MLB: Boston Red Sox -1.5 over Kansas City Royals
7:10 pm ET

The Kansas City Royals have been eliminated from playoff contention and the same should soon apply to the Boston Red Sox as they start a 3-game series tonight. The Red Sox have lost 6 of their last 8 games, while the Royals are 3-7 in their last 10. The advantage in this game goes to the Red Sox and it lies with the starting pitchers. The Royals are projected to start Jonathan Heasley while the Red Sox will counter with Michael Wacha. The separation between these right-handed pitchers can be seen in their last 7 starts. Heasley is 2-4 with a 6.75 ERA with a 1.79 WHIP. Compare that to Wacha’s last 7 starts, in which he’s a perfect 5-0 with a 3.24 ERA and a 1.01 WHIP. Read our full Royals vs Red Sox predictions.


Don’t forget to check out our daily show Let’s Bet It on our YouTube channel atyoutube.com/c/Pickswise at 10:00 am ET.

In today’s show hosts Lauren Jbara and Jared Smith will be reacting to last night’s NFL game and looking ahead to today’s MLB games and this week’s college football slate before revealing their Plays of the Day!

You can also access the show at any time through Spotify and Apple Podcasts (search for Let’s Bet It Presented By Pickswise).

The Week 2 edition of Pickwise Playbook, our weekly NFL preview show, is also available, featuring former NFL star Tank Williams, so be sure to check that out too!


Get up to speed with today’s baseball by reading our Friday MLB mega parlay and YRFI/NRFI best bets, plus a Dodgers vs Giants same game parlay.

As for college football, you can check out our CFB Week 3 Best Bets, Saturday NCAAF mega parlay and our college football underdog picks.

Our NFL Week 2 package includes Jared Smith’s NFL Week 2 picks and our Sunday 1pm NFL prop bets from Bobby “Prop Holliday” Stanley, plus our Sunday millionaire maker parlay!

The PLL lacrosse championship game is on Sunday too, and you can read our PLL best bets and lacrosse prop bets.

Read all of our great sports analysis as it arrives throughout the day on the Analysis tab.

Stat of the Day

The Dodgers have won 10 of their last 11 meetings with the Giants.

Quote of the Day

“It was just a tough NFL game and he took some big hits.”

Chargers head coach Brandon Staley is hoping Justin Herbert’s injury is not as bad as it looked.

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