Tennessee Titans vs Indianapolis Colts Prediction, Odds and NFL Picks for Sunday, 10/18/26

There are three 0-5 teams in the NFL heading into Week 6, which includes the Tennessee Titans. Tennessee’s offense is the main reason for its winless start, averaging a league-low 11.6 points per game. The Titans put together their worst offensive performance in last Sunday’s 26-3 home defeat to the previously 0-4 Texans, posting 187 yards of offense and turning the ball over twice.

The Colts saw their modest two-game winning streak end in a 34-22 setback to the Steelers, highlighted by a pair of 50+ yard TDs from Pittsburgh RB Jaylen Warren. Indianapolis was held to one touchdown for the second time in three games, as kicker Spencer Shrader has kicked 12 field goals in this span.

The Colts have swept the Titans in each of the last three seasons, including a pair of early-season blowouts in 2025. Indianapolis torched Tennessee 41-20 in Nashville, and that was followed by a 38-14 home rout as 14.5-point favorites.

The Colts rank 30th in EPA/Pass, but face a Tennessee defense that sits 27th in EPA/Pass. Last season, Colts RB Jonathan Taylor rushed for 255 yards and five TDs against the Titans. Despite the slow 2-3 start, the Colts can move to 2-0 inside the AFC South with a victory after edging the Texans in Week 3. The Titans own a 3-6 against-the-spread road record since covering the 2025 season opener at Denver.

Titans vs Colts prediction: Colts -7 (-105) available at time of publishing. Playable to that number to -115.

Tennessee has not disappointed under bettors this season with its lack of offensive prowess, hitting the under four of five times. The Titans have reached 20 points once this season, coming in the Week 2 loss in the final minute to Philadelphia. Indianapolis’ defense has been up and down so far, allowing at least 33 points in each of its three losses, but 30 total points in its two victories.

The two lowest-ranked QBs in the league meet on Sunday, as Daniel Jones and Cam Ward are at the bottom in EPA/Pass, while Ward has eclipsed 200 passing yards once. 

The Colts are the top team in the NFL in EPA/Rush, while Tennessee ranks 16th defensively in EPA/Rush. It will be interesting to see if the Colts rely on the run considering their struggles in the passing game, even though the Titans are 27th in defensive EPA/Pass. Tennessee has allowed 20 explosive plays in the past two weeks, but has yielded only two touchdowns in the last six quarters.

Both matchups last season easily hit the over, thanks to the Colts scoring a combined 79 points in the two victories. Indianapolis will look to control the ball on the ground, while Tennessee’s offense has failed to produce at key times. Look for this game to stay under the total.

Titans vs Colts prediction: Under 44.5 (-102) available at time of publishing. Playable to 43.5 (-110).