PHI vs JAX Prediction, Odds and NFL Picks for Sunday, 10/11/26

The Jacksonville Jaguars will begin their annual stay in London when they face the Philadelphia Eagles at Tottenham Hotspur Stadium on Sunday. Jacksonville comes in with a 3-1 record, while Philadelphia sits at 2-2. There is no doubt that the Jags have been the superior team so far in the early stages of the 2026 campaign, but giving more than a touchdown is steep. As such, my Eagles vs. Jaguars pick is on the underdogs to cover. London is Jacksonville's home away from home (it plays twice there each year), but the franchise is sporting an even 7-7 all time across the pond. It's not like the Jaguars have some kind of home-field advantage.

There is no doubt that the Jags have an advantage in the health department, as the Eagles' laundry list of injuries includes Saquon Barkley and DeVonta Smith. That being said, Jacksonville has two offensive linemen who are questionable and a whole host of starting defensive players who are also questionable. To be perfectly clear, I would avoid this game like the absolute plague. If you had to make a play, though, taking the points seems like the way to go.

Eagles vs Jaguars prediction: Philadelphia Eagles +7.5 (-110) available at time of publishing. Playable at that number.

What we don't know at time of publishing is who will be on the field for Philadelphia (and to a lesser extent for Jacksonville, also). What we do know is that the Eagles' offensive line is in shambles. Lane Johnson retired abruptly earlier this week and immediately thereafter they traded Cam Jurgens to the Ravens. I don't care how capable their replacements are; when an offensive line is not used to each other, the whole is less than the sum of its parts. That is a big reason why my Eagles vs. Jaguars pick is under 41.5.

Philly has not scored more than 24 points in any game this season, and it is averaging 13.5 ppg over its past two outings. Now health has become a concern offensively, too. Moreover, the Eagles have to face a Jaguars defense that has allowed 10, 20, six and 17 points so far this year. Although the Jags have been effective enough on offense, they have not had a 100-yard receiver and have not even had a 75-yard rusher in any contest. Again, any wager on this contest should be made with extreme caution -- at least until the Eagles' infirmary report is confirmed (and really the Jaguars' list, too). For now, however, I'm leaning toward the under.

Eagles vs Jaguars prediction: Under 41.5 (-105) available at time of publishing. Playable at that number.