The Buffalo Bills are the only team in the NFL that has not yet lost a road game in 2026 and they will try to keep that streak going when they visit the AFC East rival New York Jets in Week 10 on Sunday afternoon. This marks the Bills' second straight road game and fourth in the last five after they dominated at Minnesota 23-6 on Monday Night Football. The good times should continue rolling against a much worse opponent this weekend, so my Bills vs Jets prediction is for the visitors to win and cover. Since messing around with Las Vegas in a Week 6 affair that was way too close for comfort, Buffalo has won its last two contests by a combined 43 points. Four of its last six victories have come by at least eight points. Aside from a couple of dinged-up offensive linemen, it should also be noted that the Bills are among the healthiest teams in the NFL right now.
Meanwhile, New York was not even remotely competitive in a 35-12 loss to Kansas City last weekend. Receiver Garrett Wilson missed that game because of a concussion and is questionable for Sunday. The Jets are also thin on defensive depth given a whole host of injury issues. Buffalo is the only direction to look given how bad the Jets are (and given that the QB matchup is Josh Allen vs Geno Smith), but it's with minimal confidence because of the hook. It would be a different story on exactly a -7 number.
Buffalo Bills vs New York Jets prediction: Bills -7.5 (-110) available at time of publishing. Playable at that number.
Josh Allen and James Cook are playing at an elite level for Buffalo. When they are facing a mediocre defense that is allowing 24.8 points per game, it's hard to forecast anything other than a relatively high-scoring affair. As such, my Bills vs Jets prediction is Over 50.5. Allen and company are averaging 32.0 points per contest, which is good for #1 in the entire NFL. Their 386.4 yards per game are also tops in the league. We don't have a head-to-head data point yet this season, but the Bills have scored at least 30 points in three straight outings against the Jets -- including 40 at the end of the 2024 campaign.
Although New York's offense does not inspire a ton of enthusiasm, Buffalo's defense is often quite generous. That certainly wasn't the case this past week against the Vikings, but...that was the Vikings (pre-Kirk Cousins version). The Jets are at least somewhat competent on offense with Geno Smith running the show Breece Hall in the backfield. Garrett Wilson (concussion) was sidelined last weekend, but he has a good chance to return. Fellow receiver Omar Cooper Jr. (ankle) is also trending in the right direction. I can't back the under with Allen facing a generous Jets defense, but it would only be a confident play if the total was sub-50.
Buffalo Bills vs New York Jets prediction: Over 50.5 (-110) available at time of publishing. Playable at that number.
