Pickswise
Kansas City Chiefs
Oct 258:20 PMLumen Field, Seattle
Seattle Seahawks
DetailsPicks2AnalysisParlays

Kansas City Chiefs vs Seattle Seahawks Prediction, Odds and NFL Picks for Sunday, 10/25/26

🎯 Best Bet
Kansas City Chiefs
Seattle Seahawks
Kansas City ChiefsSeattle Seahawks
NFLSun, Oct 258:20 PM
Best BetPoint Spread Pick

The average NFL bettor will stumble upon this spread and immediately ask many questions. For starters, how are the 5–0 Chiefs underdogs in this spot, especially considering how clumsy the Seahawks looked last Thursday night? Kansas City, on the other hand, looks more like the championship-caliber team we were used to seeing before a regrettable 2025.

The reigning Super Bowl champions more than doubled the Broncos in total yards at Denver, but one mistake after another, most notably two interceptions by Sam Darnold, paved the runway for a Broncos win. Seahawks bettors like yours truly were dumbfounded by many of Darnold’s decisions. In Week 6, he threw 27-51 for just 5.5 yards per pass, taking five sacks as well. He has thrown seven interceptions through six games.

Still, Seattle overwhelmingly out-produced the Broncos in total yards, 353-168, and first downs, 24-13. By every metric except turnovers and penalty yardage, the Seahawks were clearly the better team, even on the road in a tough environment. With 10 days to prepare and make up for their transgressions, we imagine Seattle will look far more buttoned up in Week 7.

That still doesn't mean that they can pull away from the Chiefs. Andy Reid seems to have done it again, rebuilding a Chiefs roster that desperately needed new talent. Patrick Mahomes, who tore his ACL last December, is also playing as well as he ever has. Even with a wide receiver room that's been marred by injury, Mahomes is top-10 in QBR and owns a 3-1 touchdown-to-interception ratio. Perhaps the Chiefs’ most transformative addition is Super Bowl 60 MVP Kenneth Walker III, who leads the NFL in rushing yards (665) despite an early bye-week.

On both sides of the ball, Kansas City ranks in the top 5 in most categories. Defensively, teams can’t move the ball on them nor do they pull off explosive plays (KC is second overall). In terms of yards per game, no one is gaining more on average (414).

Everything about this contest is high-level – two Super Bowl-winning coaches, two Super Bowl-winning quarterbacks, and two defenses that are schemed and disciplined as well as any units in the NFL. Considering Seattle's clumsy performance in Week 6,  we would be shocked if they didn't come out looking more like the championship team we saw at the end of last season. From the visitors, we haven't seen anything but exceptional effort and results. This should be a very close, very entertaining clash.

Chiefs vs Seahawks prediction: Chiefs +2.5 (-110) available at time of publishing. Playable to 1.5 (-110).

Kansas City Chiefs
Seattle Seahawks
Kansas City ChiefsSeattle Seahawks
NFLSun, Oct 258:20 PM
Game Totals Pick

In terms of nerves and anticipation, there is something to be said about top-tier battles like this. Kansas City has been a part of the Super Bowl in three of the last five seasons, while Seattle is coming off another Lombardi trophy. Both programs realize that they are facing another elite. When that happens, there is an element of pride that shows in every play. In layperson terms, it’s the proverbial “we are going to prove that we are better than they are” perspective, even more so than usual, that is. In terms of how that plays out in the field, that kind of intensity usually favors defenses.

In this case, both defenses have notable matchup advantages. Both are ranked in the top five in opponent yards per carry, which should particularly benefit the Chiefs. Seattle’s rushing attack has been less than stellar, ranked 18th and averaging just 107 yards per game. Seahawks coach Mike Macdonald indicated that Zach Charbonnet, now their lead back after Kenneth Walker’s exit, has a chance to return on Sunday and receive some limited reps, Either way, Seattle will continue to roll out a random assembly of backs. That’s not ideal against KC, who allowed 73 rushing yards or less in three out of five contests.

We’re bullish that Walker will have good moments in this game. We also think he’ll be more limited than usual. Playing at Seattle against an angry defense isn’t exactly a recipe for success.

That means both offenses will be anchored by their quarterbacks. On KC’s side, that’s not a bad thing since Mahomes is playing exceptionally well, although Seattle’s defense leads the NFL in opponent yards per pass (5.2) and pass yards per game (141.3). On the other side, Sam Darnold is 31st in interceptions thrown through six games (7) and is not playing confident football. Kansas City is also right there with Seattle in opponent yards per pass (6.1), ranking in the top four.

This total is on the fringe, teasing the projection that this will be a low-total but still over the key numbers of 37, 38, 40, and 41. That’s just a tick too high.

Chiefs vs Seahawks prediction: Under 42.5 (-108) available at time of publishing. Playable to -115.

Exclusive Offers
See all
Underdog — Play $10, Get $50
Underdog
UnderdogPlay $10, Get $50
$50
Novig — Deposit $10, Get $50 in Trade Credits
Novig
NovigDeposit $10, Get $50 in Trade Credits
$50
Fanatics — Bet $20, Get $350 in FanCash
Fanatics
FanaticsBet $20, Get $350 in FanCash
$350
BetMGM — Get Up to $1500 in Bonus Bets if your First Bet Does Not Win
BetMGM
BetMGMGet Up to $1500 in Bonus Bets if your First Bet Does Not Win
$1,500
Polymarket — Deposit $10, Get a $25 Trading Bonus
Polymarket
PolymarketDeposit $10, Get a $25 Trading Bonus
$25
DraftKings — Spend $5, Get $200 In Bonus Bets + 3 Months of NBA League Pass
DraftKings
DraftKingsSpend $5, Get $200 In Bonus Bets + 3 Months of NBA League Pass
$200
Bet365 — Bet $10, Get $200 in Bonus Bets, Win or Lose
Bet365
Bet365Bet $10, Get $200 in Bonus Bets, Win or Lose
$200
Onyx Odds — Spend $10, Get $50 in Bonus Picks
Onyx Odds
Onyx OddsSpend $10, Get $50 in Bonus Picks
$50
ProphetX — Trade $50, Get $75
ProphetX
ProphetXTrade $50, Get $75
$75
Rebet — Get a 100% Deposit Match up to $100
Rebet
RebetGet a 100% Deposit Match up to $100
$100
When you click our links to visit an operator and sign up, we may receive a commission at no extra cost to you. This financial relationship helps support our site.
Pickswise
Get exclusive 
free sports picks
to your email
subscriber 1
subscriber 2
subscriber 3
18K users have
already subscribed
Enter your email address
By signing up you agree to our terms and privacy