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IND
Indianapolis Colts
Oct 49:30 AMTottenham Hotspur Stadium, London
WAS
Washington Commanders
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IND vs WAS Prediction, Odds and NFL Picks for Sunday, 10/04/26

IND
WAS
Indianapolis ColtsWashington Commanders
NFLSun, Oct 49:30 AM
Best BetValue PickPoint Spread Pick

When Washington and Indianapolis invade England, the question becomes: can the Commanders take command, or will the Colts buck and kick them where it hurts? Last weekend, Indianapolis finally earned its first win of the season -- edging out a victory over Houston by two points on a field goal after the two-minute warning. Washington also picked up its first win, knocking off the reigning Super Bowl champion Seahawks. The catch? Neither team may be as bad as its record suggests, as both have battled key injuries and suffered a string of close losses. However, if talent alone tips the scales, the Colts may hold a slight edge.

The Commanders enter Sunday's matchup without starting quarterback Jayden Daniels, who dislocated his left elbow in Dallas in a game Washington likely wins if he doesn't go down. Marcus Mariota proved capable in the victory over Seattle, but he will face a Colts secondary that has found its footing. Indianapolis held Houston to 17 points and pushed Kansas City to overtime, and that recent defensive surge is a big reason I believe the Commanders come up short across the pond.

Both teams have traveled a similar road to this point in the season. However, Indianapolis' recent spark on defense -- combined with its collection of offensive weapons -- should prove too much for Washington to overcome. Star receiver Alec Pierce won't suit up on Sunday, but quarterback Daniel Jones still has plenty of playmakers at his disposal. I expect the Colts to eclipse their team total and finish at least four points clear of the Commanders, comfortably covering the spread.

Colts vs Commanders prediction: Colts -3.5 (-110) available at time of publishing. Playable to -4.5.

IND
WAS
Indianapolis ColtsWashington Commanders
NFLSun, Oct 49:30 AM
Game Totals PickOver

The Commanders and Colts are about as evenly matched statistically as two teams can be, and both have their share of issues. Washington heads to London at 1-2, averaging 25 points and 314 total yards per game; Indianapolis also sits at 1-2, averaging 24 points and 307 yards per contest. The similarities don't stop there.

Even though these teams are nearly identical on paper, only one will leave London with a win. Indianapolis and Washington are separated by just a few percentage points in passing yards, rushing yards, yards per play and third-down conversion rate. The biggest differences come in the turnover battle and pass protection. The Commanders are plus-2 in turnover differential, while the Colts sit at minus-6 and have allowed twice as many sacks. If you follow the numbers strictly, they point to a low-scoring Washington victory. I see it differently, even if the evidence suggests otherwise.

Sometimes a team's greatest strengths can't be measured on a stat sheet. Both Washington and Indianapolis are coming off their first win of the season and will be eager to build on that momentum. The Commanders' upset of the defending champion Seahawks and the Colts' victory over division rival Houston should have both teams ready to come out swinging. While I give Indianapolis the edge, the real winners may be the bettors holding a total points over ticket.

Commanders vs Colts prediction: Over 47.5 (-110) available at time of publishing. Playable to over 48.5.

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