Boston Bruins vs Buffalo Sabres Prediction, Odds and Stanley Cup Playoffs Game 2 Picks for Today, 04/21/26

The Boston Bruins had control of Game 1 of this series until there were 8 minutes remaining in the third period. The Buffalo Sabres somehow came out with a 4-3 victory in regulation to take a 1-0 lead in the series. Game 2 will come on Tuesday night, and the vibes are high in Buffalo. The Sabres will have the momentum from Game 1 and the crowd is going to rocking once again — making the KeyBank Center a tough building in which to play. The Sabres dominated much of the series opener, out-shooting the Bruins 38 to 20. An area of concern for the Bruins is their lack of scoring depth. That was on display on Sunday, as they only received production from 4 forwards with 3 goals. The David Pastrnak trio drove all of the offense. They are going to need more from the rest of their forwards if they want to keep up with the Sabres.

The Sabres were punishing the Bruins physically, as they had 53 hits in the game. I think Buffalo is going to come out flying once again on Tuesday and lay the body every chance it gets. I don’t see the home side conceding early goals like they did in Game 1. Look for the Sabres to score the first goal and control the rest of the game from there. Give me the Sabres to take a 2-0 lead in this series.

Bruins vs Sabres Game 2 prediction: Buffalo ML (-170) available at time of publishing. Playable at that number.

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