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College Football Picks

Get free college football picks for the best action throughout 2025-26 season, including college football picks against the spread, straight-up, money line picks, and total picks (over/under). Our data-devouring experts find you the best betting trends and NCAAF picks this week.

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7:30 PM ET

Thu Sep 18

ESPN

Rice

Charlotte

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Point Spread Pick

Rice -3.5(-110)

Reasoning

The Rice Owls hit the road for Jerry Richardson Stadium in the Queen City to take on the Charlotte 49ers in an American Conference matchup. The Owls opened the season with a 14-12 win on the road against Louisiana as a 10-point underdog. While they’re 0-2 against the spread in the past 2 games, Rice lost a tough 35-9 battle against crosstown rival Houston before bouncing back with a 38-17 win over Prairie View A&M at home. Regardless of their ATS record, the Owls are playing with a lot of confidence, and they have a respectable defense, unlike the 49ers right now.

The 49ers scored a 42-35 win over Monmonth of the FCS. While a victory is nice, Charlotte allowed an FCS quarterback to throw for 410 yards. Monmouth totaled 458 yards and 28 first downs against Charlotte, too, having their way in the stadium of the 49ers. Charlotte was also sloppy, turning it over three times, while forcing zero turnovers. If the 49ers play like that against the Owls, they’re going to get their doors blown off. Charlotte is 0-2 straight up and ATS in 2 games against FBS opponents, averaging just 7 points per game, while allowing 27 points on the other side. Expect more of the same on Thursday.

Rice vs Charlotte prediction: Rice -3.5 (-110) available at time of publishing. Playable to -5.5.

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Joe Williams

7:30 PM ET

Fri Sep 19

ESPN

Tulsa

Oklahoma State

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Point Spread Pick

Tulsa +13.0(-110)

Reasoning

The Tulsa Golden Hurricane hit the road to battle the Oklahoma State Cowboys at Boone Pickens Stadium in Stillwater. Oklahoma State leads the all-time series 44-28-5, including 10 straight victories in the series since Sept. 11, 1999, including a 45-10 win last season on Sept. 14 in Tulsa. Oklahoma State is 6-1 against the spread in the past 7 meetings, with the under going 4-0.

Tulsa dropped a 42-23 game at home against Navy, failing to cover as a 14-point underdog as the over cashed. The under is 2-1 in 3 games to date, however. For Oklahoma State, the last time we saw it on the football field, it was blasted 69-3 at Oregon as a 28.5-point underdog. Oklahoma State will be champing at the bit to get back on the field after a bye win Week 3. However, Oklahoma State is 0-2 against the spread so far this season, and it’s hard to understand why the Cowboys are favored by 2 touchdowns in this one. The Golden Hurricane might not win, but a team which was dusted by 66 last time out has no business laying double digits to anybody. Take the Golden Hurricane plus the points in this one.

Tulsa vs Oklahoma State prediction: Tulsa +13 (-110) available at time of publishing. Playable to +12.5.

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Joe Williams

College Football Picks This Week

With so many conferences and hundreds of matches played every weekend, the biggest test with any college football picks is unearthing those hidden gems. Here at Pickswise, that is exactly what we do. By focusing on the Power conferences and the Top-25 teams, along with a select number of other matches, our experts can focus on the key games and leave no stone unturned in our research. Pickswise is the home of free NCAAF picks, and we break down all of today’s college football action, with each pick coming with accompanying analysis, including all of the key stats, trends, and reasons for our pick.

Be sure to check back each week during the season for all of our top college football picks today.

Expert College Football Picks Against The Spread (ATS)

The most popular college football pick is against the spread (ATS). Against the spread betting isn’t about picking a winner of the football game, it’s about picking the team who will cover the spread.

Let’s say you bet your money that Team A covers the spread (wins by a certain amount of points), Michigan State -6.5 for example. Or that Team B will cover the spread (keep the game closer than oddsmakers expect), Ohio State +6.5. If Michigan State beat Ohio State 30-27, then Ohio State covers the spread, and underdog backers are cashing tickets with +6.5 on Ohio State.

Against-the-spread betting is extremely popular in football and that’s one of the main reasons why it’s one of the most popular college football picks on our site.

NCAA Football Today – Today’s NCAAF Picks

At Pickswise we cover all of the Power NCAA football today, with full game previews, picks, and betting analysis brought to you by our college football experts. A typical college football season runs from August to December and is preceded by the College Football Bowl Season and College Football Playoff, culminating in The College Football Playoff National Championship game in January.

When Do You Post Your College Football Picks

We post our college football picks for this weekend a couple of days before the scheduled match. We post our picks early enough so that you can digest the information, do your own research into the match, and make sure you get the best lines and odds for that particular pick. Like anything in sport, some things are unpredictable, and on occasion, we may choose to delay posting a pick if there is something like a key injury or likely conditions that could have an impact on the outcome of the match, or our pick itself. Check back leading up to the weekend every week throughout the season to see what NCAAF Picks we have for today.

Free Expert NCAAF Picks

All of our NCAAF picks are absolutely free, all season long. We have a team of expert NCAAF handicappers on hand to preview the very best of the Power conference or Top-25 ranked match, every week, all season long. Each of these previews comes with our experts’ NCAAF pick on the three main markets (Money Line, Spreads & Totals) with a full breakdown of why they like a particular side, as well as a confidence rating for each individual NCAAF pick. You can find every NCAAF pick throughout the season right here on the NCAAF Picks page, or check out our NCAAF Parlays for even more insight into betting better on NCAA Football this week.