Saint Louis Billikens vs Michigan Wolverines Prediction, Odds and Picks for Today, 03/21/26

The Saint Louis Billikens meet the Michigan Wolverines in a Midwest Region second-round game at KeyBank Center in Buffalo, N.Y. on Saturday to kick off the day. Saint Louis cruised past Georgia 102-77 in the opening round, cashing as a 1.5-point favorite as the Over (167.5) cashed. Prior to that cover, SLU was just 1-5 against the spread (ATS) in the previous six, however. The Billikens have cashed the Over in two of the past three games in the postseason, including the Atlantic 10 Conference tournament. However, the Under has a 3-2 edge in five neutral-site games this season, while going 3-1 in four games against teams in the NCAA Tournament, with the lone exception for rout of UGA.

Michigan pounded 16-seed Howard 101-80, but failed to cover as a 30.5-point favorite as the Over (151.5) easily cashed. However, the Under was 2-1 in the Big Ten tournament for Dusty May’s bunch, while the Under is 5-3 in the past eight neutral-site games for the Wolverines. Michigan has also failed to cover the past six games, while going 1-8 ATS in the previous nine outings. If you’re looking for a same-game parlay (SGP) opportunity, going Under on the total, coupled with Saint Louis is the way to go. If you’re looking for just a singular play, the Billikens catching double digits is the play. Michigan is 0-6 ATS in the past six tries as a favorite of 9.5 or more points.

Saint Louis vs Michigan prediction: Saint Louis +12.5 (-115) available at time of publishing. Playable to +11.5.