Cincinnati Bearcats vs Clemson Tigers Prediction, Odds and Picks for Today, 12/21/25

The Cincinnati Bearcats of the Big 12 and the Clemson Tigers of the ACC will meet on Sunday afternoon at a neutral-site venue in Greensville, South Carolina. The Bearcats come into this game following a home win over Alabama State, which snapped a 2-game losing streak. Meanwhile, the Tigers have won 2 in a row by exactly 7 points each, with the most recent win coming at home over in-state rival South Carolina. 

This could be a low-scoring affair. Per KenPom, this is a top-35 defensive matchup; Cincinnati is 10th in adjusted defensive efficiency and 13th in opposing effective field goal percentage allowed, while Clemson is 33rd and 28th in those metrics, respectively. They both make their opponents grind for shots, as shown by Cincinnati’s rank of 256th and Clemson’s rank of 362nd in opposing average possession length. Both teams are also very good on the defensive glass, boasting top-25 marks in opposing offensive rebounding rate. Not to mention, neither team is very reliable from the three-point line. Let’s go low on the total in this one.

Cincinnati vs Clemson prediction: Under 140.5 (-110) at the time of publishing. Playable to 139.5.

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