DePaul Blue Demons vs Seton Hall Pirates Prediction, Odds and Picks for Today, 02/18/26

The DePaul Blue Demons will travel to Newark on Wednesday night to play a Big East Conference game against the Seton Hall Pirates. Neither team is a projected tournament team, but Seton Hall still has a chance to make the big dance if they can finish the season strong. DePaul is better than they have been in recent years, but they still will be in for a big challenge in this matchup. Seton Hall is currently an 8.5-point favorite, and I like Seton Hall to cover that spread.

I like Seton Hall to cover the spread in this game because their defense is one of the best in the country and they should be able to turn over DePaul at a high rate. According to KenPom, Seton Hall’s defense is ranked #7 in turnover percentage while DePaul’s offense is ranked #246. The Blue Demons average 12.1 turnovers a game and will likely struggle to take care of the ball here. I believe that the Pirates defense will be the difference in this matchup, and I expect them to cover the spread. Take Seton Hall.

*Seton Hall -8.5 available at time of publishing. Playable at -10*