DePaul Blue Demons vs Seton Hall Pirates Prediction, Odds and Picks for Today, 02/18/26

The DePaul Blue Demons will travel to Newark on Wednesday night to play a Big East Conference game against the Seton Hall Pirates. Neither team is a projected tournament team, but Seton Hall still has a chance to make the Big Dance if it can finish the season strong. DePaul is better than it has been in recent years, but it still will be in for a big challenge in this matchup. Seton Hall is currently a -8.5 favorite, and I like it to cover.

The Pirates’ defense is among the best in the country and they should be able to turn over DePaul at a high rate. According to KenPom, Seton Hall’s defense is ranked #7 in turnover percentage; DePaul’s offense is ranked #246. The Blue Demons average 12.1 turnovers a game and will likely struggle to take care of the ball on Wednesday. I believe that the Pirates’ defense will be the difference in this matchup. Let’s roll with Seton Hall.

DePaul vs Seton Hall prediction: Seton Hall -8.5 (-115) available at time of publishing. Playable to -10.

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