Duke Blue Devils vs Texas Tech Red Raiders Prediction, Odds and Picks for Today, 12/20/25

The Duke Blue Devils and the Texas Tech Red Raiders will play inside Madison Square Garden on Saturday night for a non-conference showdown. There should be numerous Duke fans that travel to the Garden for this game, giving them a great advantage. The Blue Devils have yet to lose this season, and I do not see them losing for the first time here. The spread is set at Duke -9.5 and that is my best bet of the game.

Duke to cover the spread here is my best bet because they are the more talented team and should use their defense to make it hard on Texas Tech to score. The Blue Devils are led by freshman phenom Cameron Boozer, and I see him winning the matchup against Texas Tech star JT Toppin. Texas Tech runs their offense through Toppin, but it might be hard for him to get going with Duke’s amazing interior defense. According to KenPom, Duke’s defense is ranked #1 in effective field goal percentage, #2 in two-point percentage and #3 in adjusted efficiency. They have one of the best defenses in the country and I see that being the difference here. Take Duke to cover.

*Duke -9.5 available at time of publishing. Playable at -10*