Grambling State Tigers vs Ohio State Buckeyes Prediction, Odds and Picks for Today, 12/23/25

The Grambling Tigers head to Value City Arena in Columbus looking to do a better job than its football team did against the Ohio State Buckeyes back in September. Grambling lost 70-0 in football back on Sept. 6 against the Buckeyes. The Tigers are coming in on a roll, posting back-to-back victories over Norfolk State and Hampton while going 4-0 against the spread in the past 4 outings and 7-2 ATS across the previous 9. As an underdog, Grambling has managed a 4-1 ATS mark in the past 5 since Nov. 21, too. However, in the only previous game against a power-conference team, it got blown out 102-62 by Iowa State as a 34-point underdog.

The Buckeyes are looking rebound following a heartbreaking 71-70 loss against North Carolina at State Farm Arena in Atlanta, although Ohio State did hang on for the cover as a +2.5 underdog. The Buckeyes have managed to win just twice in the past 5 games, but those losses were to power-conference teams Pitt, Illinois and UNC. As favorites of 23 or more points, the Buckeyes are 3-1 ATS in the past 4 tries with a winning margin of 53, 33, 22 and 26 in those 4 games. Look for Ohio State to roll, covering the big number in this matinee game.

Grambling State vs Ohio State prediction: Ohio State -30.5 (-110) available at time of publishing. Playable to -31.5.

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