Indiana Hoosiers vs Kentucky Wildcats Prediction, Odds and Picks for Saturday, 12/13/25

The Indiana Hoosiers will take a break from conference play when they head to Rupp Arena to take on the Kentucky Wildcats on Saturday night. The Hoosiers boast an 8-2 SU record, but have lost 2 of their last 3. They were able to snap a short, 2-game losing streak with a convincing 113-72 home win over Penn State on Tuesday in which they dropped an eye-opening 1.55 points per possession on 83% shooting from two-point range and nearly 55% from three-point range. Meanwhile, Kentucky was also able to snap a mini 2-game losing streak with its own convincing win on Tuesday, but that victory was over North Carolina Central, not a power conference opponent. 

Let’s call a spade a spade here, Kentucky hasn’t been very good against high-level opponents this year. In fact, the Wildcats are 0-4 SU against the 4 top-25 opponents they’ve played per KenPom’s rankings, which includes a 67-64 home loss to North Carolina just a few days before they were absolutely obliterated by Gonzaga 94-59 at Bridgestone Arena in Nashville.

When I wrote and published my Saturday best bet article last night, this line was at 5.5. Now sitting around 2.5 points, there’s not much value left on the spread, so let’s pivot to the money line. This is not a Kentucky defense that I trust at all in step-up games, especially on the perimeter where the Wildcats sit 223rd in three-point rate allowed. That’s not exactly a recipe for success against an Indiana team that can flat-out shoot the ball. The Hoosiers are top-40 in both three-point rate and three-point percentage, and while we haven’t quite seen that efficiency from deep on the road yet this year, Kentucky is likely to give them plenty of chances to heat up from range.

Indiana vs Kentucky prediction: Indiana Hoosiers ML (+134) at the time of publishing. Playable to +110.

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