Louisville Cardinals vs Indiana Hoosiers Prediction, Odds and Picks for Today, 12/06/25

The Louisville Cardinals and the Indiana Hoosiers will meet for a non-conference game in Indianapolis on Saturday. It will be a top-25 showdown at Gainbridge Fieldhouse and Hoosiers fans should be there in great force. Indiana fans can attend this marquee non-conference game before heading down the street to Lucas Oil Stadium to see its football team play Ohio State in the Big Ten Championship. I expect the arena to be mainly Indiana fans, but my best bet of the game is the over.

The total is currently set 159 points and that is too low for my liking. I expect this game to possibly finish in the 80s for each team due to the pace of the game and Louisville’s high-powered offense. The Cardinals will look to speed things up and get up 3s at a high rate. They are ranked #2 in the nation in 3-point attempts per game and 3-point field goals made per game. According to KenPom, Louisville is ranked #10 in average offensive possession length and #47 in adjusted tempo, which is why you should expect a fast-paced game. Louisville’s offense is ranked as the #4 offense in the country in adjusted efficiency and is averaging 94.6 points per game. The Cardinals should have little issue putting up points in this one.

Neither Louisville nor Indiana has been great on defense this year, so the offense should be on full display under the bright lights in the Pacers’ home arena. According to Bart Torvik, both teams rank outside the top 80 in adjusted defensive efficiency against top-100 opponents this season. I expect shots to go in at a high rate in this game and the total to go over 159. I’m backing the over.

Louisville vs Indiana prediction: Over 159 (-110) available at time of publishing. Playable to 160.

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