Louisville Cardinals vs Pittsburgh Panthers Prediction, Odds and Picks for Today, 01/17/26

The Louisville Cardinals and the Pittsburgh Panthers will face off on Saturday for an ACC matchup. Louisville was expected to compete with Duke at the top of the conference this season but has started ACC play just 2-3. The Cards have been without 5-star freshman Mikel Brown Jr. and will miss him again on Saturday. Pittsburgh is 8-9 on the season and is projected to miss the NCAA Tournament. The Panthers are an underdog in this one, but my best bet of the game is the under.

I like the under because Louisville’s offense has not been the same with Brown out of the lineup and Pittsburgh does not have a good offense. The Panthers are ranked #196 nationally in points per game and rank #63 in opposing points per game. The Cardinals’ offense has failed to score more than 75 points in their last 3 games, and the possessions should be limited against a Pittsburgh team that will try to slow the pace. The Panthers ranked just #333 in adjusted tempo — that should translate into the total staying under the number.

Louisville vs Pittsburgh prediction: Under 152.5 (-110) available at time of publishing. Playable to 150.

You can bet on our Louisville vs Pittsburgh pick with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first $10+ wager is a winner!