Oklahoma State Cowboys vs Colorado Buffaloes Prediction, Odds and Picks for Today, 02/21/26

The Oklahoma State Cowboys head to the CU Events Center in Boulder to take on the Colorado Buffaloes. These are a couple of the weaker Big 12 teams, although the Cowboys have picked up the pace lately, and they’re been a little bit of a thorn in the side to some of the contenders. Oklahoma State won the first-ever conference meeting between these teams, at least the latest installment as Big 12 members again, posting an 83-73 win as a 4-point favorite last season in Stillwater. OK State is just 1-5 in 6 true road games, and it has lost 4 in a row, while going 0-4 against the spread in that span. Furthermore, the Under is 3-1 in the past 4 games, and 7-2 across the past 9, and that’s what we’ll focus upon.

Colorado had had a pitiful defense this season, allowing 78.6 PPG (275th in the nation), a 46.0 percent (281st) defensive field-goal percentage and a 37.6 percent (356th) defensive 3-pointer percentage. While the defense continues to struggle, allowing 78+ points in 5 of the past 7 games, the offense has also had a rough time. As such, the Under is 4-1 in the past 5 games, and 9-3 in the past 12 outings. The total for this game is super high, so let’s go low on the total, and feel confident in doing so.

Oklahoma State vs Colorado prediction: Under 163.5 (-115) at time of publishing. Playable to 161.5.

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