Oklahoma State Cowboys vs Iowa State Cyclones Prediction, Odds and Picks for Saturday, 01/10/26

The Oklahoma State Cowboys head north to Hilton Coliseum in Ames, Iowa for this Big 12 conference tilt against Iowa State. The Cowboys have won four of the past five meetings, while going 4-1 against the spread (ATS), and OK State is 8-2 SU in the previous 10 battles dating back to Feb. 29, 2020, with the Cowboys going 7-3 ATS in that span. The Cowboys not only covered as a double-digit underdog in the most recent meeting last season Feb. 25, 2025 in Stillwater, but it won outright as an 11-point ‘dog. In fact, OK State has won three of the past five meetings outright despite being an underdog. It is also 3-1 SU/ATS in the past four trips to Ames.

The Cyclones are 15 up, and 15 down so far, yet to suffer a defeat. It picked up a 70-60 win at Baylor last time out as a 4.5-point favorite, but it is just 2-4 ATS in the past six games. As a double-digit favorite, Iowa State is just 1-4 ATS in the past five instances. Laying more than nine buckets against a Cowboys team which has just two losses on the season is quite a bit. OK State is likely to feel quite disrespected. It usually rises to the level of its competition, so expect the Cowboys to keep this one closer than 19 points.

Oklahoma State +18.5 (-110) at time of publishing. Playable to +17.