Ole Miss Rebels vs NC State Wolfpack Prediction, Odds and Picks for Today, 12/21/25

The Ole Miss Rebels of the SEC will head to Greensboro, North Carolina for a neutral-site contest with the NC State Wolfpack of the ACC on Sunday afternoon. The Rebels are 7-4 SU this year, but they aren’t very good in the eyes of bettors – failing to cover the spread in 9 of those 11 games. The Wolfpack are 8-4 SU and 5-6-1 ATS ahead of this non-conference contest, having covered just once in their last 5 games. Moreover, NC State is just 1-3 ATS as a favorite of less than 10 points, which makes me wary of the Wolfpack’s chances of covering this number – even against a team that is as bad as Ole Miss against the spread. 

For as bad as the Rebels are against the number, each of their 4 losses were by 9 points or less and 3 of them by 5 points or less. There’s reason to think they can keep this one close, as they succeed in limiting transition opportunities and rim attacks while efficiently guarding attack-and-kick sets and cutting big men per Hoop-Explorer – all areas NC State excels offensively. Look for the Rebels to make the Wolfpack uncomfortable on Sunday. 

Ole Miss vs NC State prediction: Ole Miss Rebels +7 (-110) at the time of publishing. Playable to +6. 

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