Pittsburgh Panthers vs Villanova Wildcats Prediction, Odds and Picks for Today, 12/13/25

The Pitt Panthers make the trek across the Keystone State to battle the Villanova Wildcats looking to turn things around. Pitt suffered an 80-73 loss at home against Hofstra as a 9-point favorite, going 1-4 straight up and against the spread in the past five games. As an underdog, Pitt is 1-2 ATS this season. However, in this series, the Panthers have not only won each of the past six meetings in this series since Feb. 21, 2010, but the Panthers are 5-1 ATS in that span, too.

For Villanova, it heads in looking to redeem itself after an ugly 89-61 beatdown from Michigan last time out on Tuesday. That halted a seven-game win streak for the Wildcats, although they’re just 3-3 ATS in the span. Villanova is just 3-2 ATS in the past five games as a double-digit favorite, too. The Wildcats have managed 80.7 PPG, while hitting 46.8 percent from the field, while going 36.5 percent from behind the three-point line. Defensively, Villanova has managed to allow 69.0 PPG, although teams are hitting 44.8 percent against them, while the Wildcats have one of the worst defensive three-pointer percentages at 39.8 percent. Look for Pitt, who hits at a 34.3 percent mark from downtown, to stay in the game and cover thanks to its perimeter shooting.

Pitt +10 (-110) at time of publishing. Playable to +8.5.