San Diego State Aztecs vs Arizona Wildcats Prediction, Odds and Picks for Today, 12/20/25

The San Diego State Aztecs are 6-3 SU and will take their 3-game winning streak to Phoenix to play the top-ranked Arizona Wildcats in what is technically a neutral-site game despite being in close proximity to Tucson. The Wildcats are a perfect 10-0 SU, and they pay bettors more often than not – covering the spread in 7 of those 10 contests. The Aztecs are not nearly as profitable against the number, covering in just 3 of their 9 contests. 

The Wildcats look like title contenders early on, as they are highly efficient both offensively and defensively – sitting top-10 on both ends of the floor per KenPom. Their elite size makes them lethal at and around the rim, on the glass, and in their defensive sets, which figures to overwhelm the Aztecs. Outside of Magoon Gwath – a great shot-blocker in his own right – San Diego State does not have much size to contest the likes of Koa Peat, Motiejus Krivas, and Tobe Awaka.

Expecting Arizona to dominate the glass on both ends, and with San Diego State regressing defensively from what it usually is under Brian Dutcher, the Aztecs are going to need to continue their red-hot shooting from the perimeter to keep this one close. Unfortunately, I don’t see that happening against a long defense like Arizona that can contest almost any shot on the floor. At near 41.5%, the Aztecs are the 4th-best three-point shooting team in the country, but I don’t think it’s sustainable. Not to mention, SDSU is 285th in turnover rate. 

San Diego State vs Arizona prediction: Arizona Wildcats -14.5 (-110) at the time of publishing. Playable to -15.

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