South Florida Bulls vs Louisville Cardinals Prediction, Odds and Picks for Thursday, 03/19/26

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After a long and eventful regular season and the beautiful chaos of Championship Week, the best time of year is finally here. March Madness has arrived and with it comes a plethora of games for us to dig into over the course of a couple of action-packed days. One of the first games on Thursday’s slate comes in the East Region between Louisville and South Florida in what should be a battle of teams that mirror each other a bit in certain areas. The Bulls are a side that I’ve enjoyed backing down the stretch and South Florida comes into this contest having won 11 straight games, with most of those victories coming by double digits. Conversely, Louisville is on the opposite end of the spectrum, having dropped 4 of its last 8 games after bowing out in the quarterfinals of the ACC tournament. There are some serious warning signs that suggest the Cardinals should be on upset alert, and this is a solid spot to take a shot on USF in a matchup where they should hold some crucial edges.

The Bulls are unlike some of the other popular mid-major picks that you’ll see in many brackets this time of year, and it’s largely due to the fact that their roster is littered with high-major transfers and veteran players who are not new to this sort of high-pressure situation. Bryan Hodgson’s team starts a trio of excellent seniors, including Izaiyah Nelson — the AAC Player of the Year. The Bulls typically employ a 7-man rotation, and 5 of those players are upperclassmen who have played dozens of games at this level. There won’t be an intimidation factor in this game, and given the fact that South Florida has been a top-35 team since February 1 per BartTorvik, the Bulls are certainly trending in a better direction compared to their opponent.

It all starts on defense, with South Florida sitting inside the top 40 in adjusted efficiency and 24th in two-point percentage defense on the year. On offense, the Bulls are a dominant unit in transition in league play, and we saw them use that comfort of playing at a very fast tempo to great advantage during the conference tournament. Furthermore, South Florida should be very competitive in the shot volume battle in this matchup, seeing as its ranked 6th in offensive rebounding percentage on the season, while Louisville sits at 168th over the last 2 months in that same statistic (BartTorvik). On the other side, Louisville has struggled away from home all season long, and the Cardinals’ are also at the mercy of a nagging lower-back injury that has caused Mikel Brown Jr. to miss 10 games this season. If Brown Jr. is unable to play or is limited in this game, the Louisville offense would certainly take a major hit. Even if Brown is a full-go, I like the matchup for South Florida and think the Bulls can spring the upset. With that in mind, I’ll back USF with the points on Thursday.

South Florida vs Louisville prediction: South Florida +6.5 (-120) available at time of publishing. Playable to USF +5.5