St. John's Red Storm vs Connecticut Huskies Prediction, Odds and Picks for Today, 02/25/26

One of the biggest games on the Wednesday college basketball slate comes in Storrs, Connecticut, where the UConn Huskies will host St. John’s in a massive Big East rematch of a meeting we just saw a few weeks ago. In that first matchup between these teams, St. John’s was the more aggressive unit by far, as the Red Storm took it to the Huskies in a fairly convincing 81-72 win at Madison Square Garden. UConn stumbled again a week ago at home against Creighton, but the Huskies bounced back nicely with a very solid performance in a win at Villanova over the weekend. Danny Hurley’s group hasn’t always been at their best in conference play, but his teams have traditionally rounded into form heading into March, and that should once again be the case on Wednesday.

Even after removing the obvious revenge angle and Hurley’s track record when facing an opponent a second time in the same season, this should be a chance for UConn’s defense to assert its will and establish control of the game early on. After all, St. John’s offense is barely ranked inside the top 50 in adjusted efficiency per KenPom, and the Red Storm did a ton of damage in that first meeting around the basket. I have full confidence in Hurley and his staff to come up with a much better gameplan this time around, one that limits St. John’s effectiveness inside and forces the Red Storm to be a perimeter jump-shooting team. UConn also turned the ball over 15 times in that previous matchup, so if the Huskies are able to avoid those self-inflicted wounds, that should limit St. John’s ability to get key buckets in transition and force Rick Pitino’s team to consistently score in the halfcourt against a UConn defense that is 12th in adjusted efficiency and 8th in effective field goal percentage allowed. Finally, the Huskies should have healthier versions of Braylon Mullins and Alex Karaban on the floor in this one, so let’s lay the points with the home team on Wednesday.

St. John’s vs UConn prediction: UConn -4.5 (-110) available at time of publishing. Playable to UConn -5.5

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