Towson Tigers vs Kansas Jayhawks Prediction, Odds and Picks for Tuesday, 12/16/25

The Towson Tigers hit the road to battle the Kansas Jayhawks, and Towson hopes that the third time will be the charm. It has faced three Big 12 teams this season, and the results haven’t been great. Towson was thrashed 86-61 as a 9-point underdog on Dec. 7 in the most recent outing as the Under (148) cashed, while it also lost 65-48 at Houston back on Nov. 8, although it did cover as a 26-point underdog as the Under (130.5) cashed. The Tigers have allowed 80 or more points in three straight outings against UCF, Cornell and UC San Diego.

The big news for Kansas is that NBA prospect and potential lottery pick Darryn Peterson is questionable due to a quadriceps injury. He left the thrilling overtime road win at NC State on Saturday early due to injury. To make matters worse, depth player Samis Calderon is battling an illness, and he, too, is listed as questionable. Peterson is the big story, though. It wouldn’t be crazy for Kansas to rest him, and it might be why the sportsbooks have installed the ranked Jayhawks as only a moderate favorite despite the fact it should get the win handily if both sides were healthy. Still, KU is deep enough to get the job done, but my confidence is lower if Peterson is out. There is no still word on if he’ll play or not, so tread lightly on Tuesday.

Towson vs Kansas prediction: Kansas -15.5 (-110) at time of publishing. Playable at that number.

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