Vanderbilt Commodores vs Memphis Tigers Prediction, Odds and Picks for Today, 12/17/25

The Vanderbilt Commodores and the Memphis Tigers will face off on Wednesday night for a non-conference showdown. The Commodores have been a great surprise to college basketball starting the season 10-0. They are now ranked #13 in the country and will look to keep their undefeated season going with a win here. Memphis is just 4-5 on the season and may struggle to get a much-needed home win against Vanderbilt. The spread is currently Vanderbilt -7.5, but my best bet of the game is the over.

I like the over in this game because Vanderbilt has one of the best offenses in all of college hoops. They are ranked #2 nationally in points per game at 95.4 and have yet to score less than 80 points in any game this year. According to KenPom, their offense is ranked #4 in adjusted efficiency, #4 in two-point percentage and #7 in effective field goal percentage. I do not see Memphis slowing them down in this one as their defense is ranked just #51 in adjusted efficiency and outside the top 100 in two-point percentage. The Commodores should be able to score at a high level in this one and I expect the pace to be fast.

Vanderbilt will look to play fast, which should help drive the total over. They are ranked #5 in adjusted tempo and #34 in average offensive possession length while Memphis is ranked #133 in adjusted tempo. I see a fast-paced game with no shortage of points here. Take the over.

*Over 159 available at time of publishing. Playable at 160*