Xavier Musketeers vs Georgetown Hoyas Prediction, Odds and Picks for Saturday, 12/20/25

The Xavier Musketeers hit the road for the nation’s capital looking to stay hot in this series. Xavier has picked up victories in six of the past seven meetings in the series, although Georgetown has covered each of the past 5 meetings. The underdog is 4-1 against the spread (ATS) in the past 5 in the series, and 6-3 ATS across the past 9 encounters. For the Musketeers, they’re a solid 6-2 ATS in the past 8 games, and transfer portal addition Tre Carroll from FAU is playing good basketball lately. This Xavier team was crushed last time out against Creighton, but it has won five of the past six outings. Look for the embarrassed Musketeers to come out with a chip on their collective shoulders.

The Hoyas won and covered at Marquette last time out, 78-69, as a 7-point underdog, but they’re still just 1-6 ATS in the past seven games, and they’re split the previous six outings 3-3 SU. Defense has been a struggle at times, allowing 74 or more points in 6 of the past 8 outings. Xavier should be able to pick apart Georgetown’s shaky perimeter defense, as the Hoyas are jus 196th in the nation with 33.2 percent allowed on triples. That’s where Xavier will get the job done on the road.

Xaviers vs Georgetown prediction: Xavier +4.5 (-110) at time of publishing. Playable to +3.5.

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