Arizona State Sun Devils vs Mississippi State Bulldogs Prediction, Odds and Picks for Today, 09/06/25

This number absolutely stinks. Let’s profile both combatants. Arizona State is flirting with a top-10 ranking, fresh off a CFP appearance and Big 12 title in 2024. Many analysts have even touted the Sun Devils as the best team in the Big 12 with Kenny Dillingham at the helm. There was no trouble in Week 1 for ASU in dispatching an FCS opponent. No scare, no upset alert, just pure dominance and control. Now, we have the Bulldogs who were the worst team in the SEC in 2024, upset by Toledo in Starkville along the way, on upset alert again heading into their tilt with Southern Miss, last Saturday. The ‘Dogs didn’t dismantle the Golden Eagles, they won by 17 as a 14-point favorite. So the line makes no sense here.

If this game plays out as the oddsmakers prognosticate, the Bulldogs are going to be in position to pull the upset. If Mississippi State is going to be within a touchdown of a top-10 ranked team, there is a good chance that some mayhem is going to unfold and that’s why I am saying keep the points, we’ll go for the outright win with Mississippi State. If you want to play it conservative, sure, grab the converted touchdown and make it a half-unit play. But I don’t think you’ll need it. The line smells a rat, and more chaos continues Week 2 with another ranked team going down. Arizona State is not the same ASU as last year and neither are the ‘Dogs for that matter. Bulldogs win.

Arizona State vs. Mississippi State prediction: Mississippi State ML (+210) available at time of publishing. Playable at that number.

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