College Football Week 2 Betting Guide: CFB Expert picks for Saturday, September 6

UpdatedSep 15, 2026

Reading time2 min

College football Saturday is upon us once more with an action-packed slate of games for September 6. Week 1 saw the Pickswise CFB team start hot, as they went 7-0 on Thursday and 7-2 on Friday, so let’s see if we can ride that positive momentum into this week’s matchups. You can find out all of our NCAAF picks and CFB predictions for Saturday’s matchups, plus we have our college football expert’s best bets of the day, along with our parlays and Same Game Parlay picks to help you bet better across all of the action. Let’s dive in!

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College football Week 2 best bets

CFB Week 2 best bets — our experts have started the new season hot with a 6-3 record! Find out Caleb Wilfinger’s 4 best bets for Saturday

College football Week 2 parlays

Go for the big payday on Saturday with our team’s top parlays for the action:

College football Week 2 parlay — lock in Sam Avellone’s 3-leg CFB parlay for a +530 payout!
Ole Miss vs Kentucky Same Game Parlay — grab our expert’s SGP for this SEC showdown
Michigan vs Oklahoma Same Game Parlay — get some extra action on this ranked matchup with our expert’s SGP picks

College football Week 2 picks

Below, you’ll find our betting previews and NCAAF predictions for all the biggest matchups in Week 2. You can also check out our college football picks for our experts’ top picks across all of Saturday’s games.