Arizona Wildcats vs Colorado Buffaloes Prediction, Odds and Picks for Today, 11/01/25

The Arizona Wildcats hit the road looking to turn things around after dropping the past two games against BYU and Houston. The BYU was particularly tough, coming in overtime. The defense started out hot in the non-conference schedule, but it isn’t Desert Swarm anymore. Arizona has allowed at least 31 points in three of the past four games, with the lone exception coming in a 41-13 win over lowly Oklahoma State. The Over is 3-1 in the past four games, too. And, for same-game parlay (SGP) bettors, the Wildcats are just 1-3 ATS in the four-game span, so keep that in mind.

For Colorado, it was waylaid by Utah last weekend, falling 53-7 in Salt Lake City, coming nowhere near a cover as a 14-point ‘dog. The Over (50) cashed, halting a 3-game run to the Under. The defense has allowed at least 24 points in three of the past four games, and an average of 32.3 PPG in the four-game span, and 30.8 PPG in the past six outings. The offense is also good for 20 or more points in seven of eight games this season, so this could be a high-scoring, entertaining Pac-12 battle between two teams desperate for victories.

Over 52.5 (-110) at time of publishing. Playable to 53.5.