Arizona Wildcats vs Colorado Buffaloes Prediction, Odds and Picks for Today, 11/01/25

The Arizona Wildcats hit the road looking to turn things around after dropping the past 2 games against BYU and Houston. The BYU was particularly tough, coming in overtime. The defense started out hot in the non-conference schedule, but it isn’t Desert Swarm anymore. Arizona has allowed at least 31 points in 3 of the past 4 games, with the lone exception coming in a 41-13 win over lowly Oklahoma State. The Over is 3-1 in the past 4 games, too. And, for same-game parlay bettors, the Wildcats are just 1-3 ATS in the 4-game span, so keep that in mind.

For Colorado, it was waylaid by Utah last weekend, falling 53-7 in Salt Lake City, coming nowhere near a cover as a 14-point ‘dog. The over (50) cashed, halting a 3-game run to the Under. The defense has allowed at least 24 points in 3 of the past 4 games, and an average of 32.3 PPG in the 4-game span, and 30.8 PPG in the past 6 outings. The offense is also good for 20 or more points in 7 of 8 games this season, so this could be a high-scoring, entertaining Pac-12 battle between two teams desperate for victories.

Arizona vs Colorado prediction: Over 52.5 (-110) at time of publishing. Playable to 53.5.

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