California Golden Bears vs San Diego State Aztecs Prediction, Odds and Picks for Today, 09/20/25

The Cal Golden Bears make the trip from the Bay Area to San Diego looking to take care of the Aztecs. Cal has won all three of its games to date, including a 27-14 win over Minnesota last time out as a 3-point underdog. Cal was also successful in its only previous road trip, spanking Oregon State 34-15 at Reser Stadium in Corvallis. That’s two games against FBS opponents, and two covers. Cal is a solid passing team, with budding superstar QB Jaron-Keawe Sagapolutele leading the way. RB Kendrick Raphael is a solid, yet unspectacular back, ready to carry the mail when needed.

For the Aztecs, it pounded Stony Brook of the FCS by a 42-0 count, covering a 19.5-point spread as the under cashed. We can toss that game out, though, as the San Diego State defense isn’t that good. We got a better idea of its play in a road trip to Washington State, as the Aztecs were lit up 36-13 while the over (46.5) just came in. Against an FBS team, San Diego State should struggle again, especially on defense. The spread of -13 for Cal is a little much, but it’s hard to trust San Diego State. Instead, let’s look to the over. The Aztecs have posted one over in one game against an FBS opponent, while the Golden Bears have hit the over in both tries against FBS foes.

California vs San Diego State prediction: Over 47.5 (-110) at time of publishing. Playable to 48.

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