Coastal Carolina Chanticleers vs South Carolina Gamecocks Prediction, Odds and Picks for Today, 11/22/25

It’s been a rough year for the South Carolina Gamecocks, who have lost 5 straight and 7 of their last 8 after Saturday’s cataclysmic meltdown in College Station. South Carolina held a 30-3 lead at halftime over No. 3 Texas A&M, but forgot to come out of the locker room after the intermission. The Gamecocks never scored another point and eventually lost the game 31-30. 

Objectively, the Gamecocks have had a brutal schedule, as 6 of their last 7 opponents were all ranked at the time of kick-off. Going one step further, each of their last 4 opponents are squarely in the College Football Playoff picture among the top-12 teams in the country. However, that won’t be the case this week, as the Gamecocks will benefit from the classic late-season SEC buy-game when they host the Coastal Carolina Chanticleers on Saturday (even as an SEC fan, I hope these go away with the new 9-game conference schedule) .

Some will argue that this will be a flat spot for South Carolina off the heartbreak at Texas A&M, especially considering the Gamecocks won’t make a bowl and have their rival Clemson on deck. However, I disagree with that sentiment and would argue the Gamecocks will use this as an opportunity to unleash frustration on an inferior opponent. It’s certainly a massive number to lay with a team that has not instilled much trust in bettors alike, but the talent gap in this matchup is massive – and there is certainly nothing to write home about this Coastal Carolina defense. The ‘Chants are outside the top 100 in yards per play allowed this year, and more recently, they are 75th in points allowed per quality drive and 98th in PPA per play since Week 8. Look for the Gamecocks to finally have a complete performance in this one. 

Coastal Carolina vs South Carolina prediction: South Carolina Gamecocks -23.5 (-115) at the time of publishing. Playable to -24.

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