Delaware Fightin' Blue Hens vs Jacksonville State Gamecocks Prediction, Odds and Picks for Wednesday, 10/15/25

The Delaware Blue Hens hit the road for southeastern Alabama to battle the Jacksonville State Jaguars on Wednesday night in Conference USA play. The Blue Hens are 1-1 inside the conference, while the Gamecocks are 2-0 inside the league. Delaware suffered a 27-24 loss to Western Kentucky last time out, suffering its first conference setback. It also halted a 2-0-1 against the spread (ATS) run. The Under has cashed in four of five games for the Blue Hens, with mixed results on both offense and defense. The defense has allowed 27 or more points in three of the past four games, while the offense has posted 38 or more points in two of the previous three outings.

For Jacksonville State, it posted a 29-27 win at Sam Houston State, but it failed to cover as a 7-point favorite. The Gamecocks have alternated losses and wins in the six games to date, while going 0-4 ATS in the past four outings. The Over is 4-1 in the past five for JSU, and that’s why we’re shying away from the total. Delaware is a lot more consistent against the spread, while Jacksonville State hasn’t been able to cover the number lately. Let’s side with the Blue Hens to get the job done on the road, bouncing back from the disappointment of the WKU loss.

Delaware -2 (-110) at time of publishing. Playable to -3.