FIU Panthers vs Missouri State Bears Prediction, Odds and Picks for Today, 10/29/25

The FIU Panthers take the trip to Missouri State to tangle with the Bears. FIU is looking to avoid its third conference loss, and fifth overall, which would all but end any hope of a conference championship, while taking a big hit to the bowl possibility. FIU had lost back-to-back games by 22 or more points to Delaware and UConn Sept. 20-Oct. 4, but it surprised Western Kentucky as a 10-point underdog Oct. 14. However, FIU was back to its losing ways in a 45-26 loss to Kennesaw State. The Panthers have allowed 38 or more points in each of the past 3 games, and 28 or more points in 5 of the past 6 outings.

For Missouri State, it was trampled 73-13 at USC in the opener. That was the last over result, as the under has connected in six in a row for the Bears. The Missouri State run game is terrible, going for just 106.3 rushing yards per game, and it scores just 22.0 PPG. On defense, the Bears are decent, but not great. Don’t expect this to be a defensive slog, but with the struggles of Missouri State on offense, it likely won’t be able to take advantage of the FIU defense like most others do. We’ll roll with the under on Wednesday.

FIU vs Missouri State prediction: Under 50.5 (-110) available at time of publishing. Playable to 49.5.

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