FIU Panthers vs Penn State Nittany Lions Prediction, Odds and Picks for Tomorrow, 09/06/25

The Panthers of Florida International head north to battle the No. 2 Penn State Nittany Lions on Saturday in Happy Valley. FIU picked up a 42-9 victory over Bethune Cookman of the FCS, covering as a 26.5-point favorite last Friday with the Under (54) cashing. FIU piled up 28 first downs, while going 8-of-14 on third-down efficiency, while posting 456 total yards, including 223 yards on the ground. The Panthers had 5.9 yards per rushing attempt, too, but that’s going to go down a ton against the defense of Jim Knowles and the Nittany Lions.

Penn State hammered Nevada by a 46-11 score, piling up 25 first downs, while totaling 438 total yards, including 303 via the air. QB Drew Allar completed 22-of-26 passes for 217 yards, one touchdown and no interceptions. The Nittany Lions were able to force three turnovers, finishing with a plus-3 turnover ratio. That’s going to be a theme in Saturday’s game against FIU, too, as the Panthers are likely to give the ball up, and things should snowball after that. Penn State piled up 46 points against Nevada, and we’re likely to see them get to the 50’s in Saturday’s game. The Over is a strong play, as a result. It wouldn’t be shocking to the Nittany Lions do most of the heavy lifting to get this one Over the total.

Over 55 (-110) at time of publishing. Playable to 56.5 (-110).