Florida State Seminoles vs NC State Wolfpack Prediction, Odds and Picks for Friday, 11/21/25

The Florida State Seminoles hit the road for Raleigh on Friday night, and this battle against NC State will come with bowl eligibility for the winner. Both teams enter with five victories, one short of bowl eligibility. FSU has had its issues on the road this season. It all started with a stunning 46-38 loss in overtime at Virginia, and the season has spiraled from that point. It is 0-3 straight up (SU) and against the spread (ATS) in three game away from home, including a 20-13 loss at Stanford on Oct. 18 as a 17.5-point favorite, and a 24-10 loss at Clemson in the most recent trip on Nov. 8. That’s just 11.5 PPG scored on offense, with 22.0 PPG allowed on defense.

For NC State, it was humbled 41-7 at Miami last Saturday, a disappointing result after two weeks off following a massive 48-36 win in Raleigh against previously unbeaten Georgia Tech on Nov. 1 as a 5.5-point underdog. Still, NC State is just 1-3 SU and ATS in the past four games, but at home it is 4-1 SU, and 3-1 ATS in the past four. Florida State hasn’t shown an ability to win on the road, so let’s keep rolling with the opponent in those spots, especially since the Wolfpack are catching points at home. NC State is 5-2 ATS in the past seven in the series, too, winning each of the past three meetings in Raleigh since Nov. 3, 2018.

Florida State vs NC State prediction: NC State +4.5 (-110) available at time of publishing. Playable to +3.5.

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $200 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ FSU vs NC State predictions.