Florida State Seminoles vs Stanford Cardinal Prediction, Odds and Picks for Today, 10/18/25

The Florida State Seminoles hit the road for the west coast looking to pull out of a 3-game nosedive. This is an FSU team that beat Alabama at home as a 13.5-point underdog, but one which has also dropped 3 games in a row at Virginia and at home to Miami and Pittsburgh. In fact, it is not only winless inside the conference, but Florida State is 0-3 ATS against ACC opponents, too. It lost its only road game against the Hoos on a Friday night, falling 46-38 in overtime as a 7-point favorite on Sept. 26. It failed to win or cover as a double-digit favorite against Pitt last Saturday, too.

Stanford is a work in progress. The Cardinal have former QB Andrew Luck as its general manager, while leaning upon former NFL QB and head coach Frank Reich as the interim leader. The results have been mixed, going 0-4 SU/ATS on the road, but the Cardinal have scored home wins against both Boston College and San Jose State, going 1-1 ATS in those games. The over has cashed in 3 of the past 4 games, and each of the 2 home games to date, too, if you’re looking for a same-game parlay opportunity. With the way FSU is playing, though, it might be a bit disinterested in the midst of a 3-game skid, as expectations have hit an all-time low, and the good feeling of the Bama win has long since subsided.

Florida State vs Stanford prediction: Stanford Cardinal +18 (-110) at time of publishing. Playable to +17.5.

You can bet on our Florida State vs Stanford pick at DraftKings Sportsbook, which has thousands of betting options available and a great new customer offer where you can get $200 in bonus bets instantly AND $200 off NFL Sunday Ticket! Click here 👈🏼 to sign up for a DraftKings account now.