Illinois Fighting Illini vs Washington Huskies Prediction, Odds and Picks for Saturday, 10/25/25

It’s not the biggest matchup on the board, but one of the biggest games in Big Ten on Saturday comes in Seattle, where the Washington Huskies will host the Illinois Fighting Illini in a clash between a pair of teams that are looking to stay alive and preserve an outside shot of competing in the College Football Playoff race. A week ago, Washington fell to Michigan in a game that was a lot closer than what the final score indicated. The Huskies haven’t been great on the road by any means this season, but this is still one of the best home field advantages in the sport and it should claim another victim on Saturday.

While the prevailing thought would be to back the Illini catching points coming off a bye week, I’m more inclined to look toward Washington in a game where I have real matchup concerns for Illinois for a second straight week. After all, this is an Illinois defense that has struggled mightily when stepping up in class this season, and the Washington offense is one of the top 10 units in the sport (7th in success rate, 4th in quality drive rate, 5th in third down success rate). Outside of a difficult game against Ohio State — arguably the best defense in the country — this has been an excellent unit, and I’m of the belief that Demond Williams Jr, Jonah Coleman, Denzel Boston and company should be able to generate success against an Illinois defense that is shockingly poor in the secondary (125th in passing success rate allowed, 117th in points per drive allowed). We know that the Illini struggled against the dynamic USC offense, and while Washington doesn’t necessarily pose the same challenges as USC’s top-ranked passing game, this is still an offense that is as good as any across the nation when playing at home. On the other side, the Illini offense has been solid through the air, but this is still a unit that struggles mightily on 3rd and 4th down (77th in success rate on late downs per CFB-Graphs) and has not experienced much success on the road this season. Ultimately, I’ll lean on the hosts to win and cover this short number in what should be a frenzied scene in Seattle.   

Illinois vs Washington prediction: Washington -3.5 available at time of publishing. Playable to 4. 

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