Iowa State Cyclones vs Arkansas State Red Wolves Prediction, Odds and Picks for Saturday, 09/13/25

The Iowa State Cyclones will travel south this Saturday to take on the Arkansas State Red Wolves, as both teams are coming off an in-state rivalry game last weekend. Iowa State defeated the Iowa Hawkeyes 16-13 to move to 3-0 on the season. This was a tightly played, defensive game as most Iowa State-Iowa games are. Rocco Becht threw for a total of 134 yards, and he led his team 55 yards in the final minutes to allow for a game-winning 54-yard field goal.

Arkansas State lost their previous game 56-14 against Arkansas. Arkansas jumped out to a 2-touchdown lead in the first 5 minutes of this game and never looked back. Arkansas State was dominated on the ground, allowing 191 yards rushing on 10 attempts in the first quarter alone. Arkansas State’s quarterback, Jaylen Raynor, finished the game with 125 yards passing, 1 touchdown, and 2 interceptions.

Iowa State has been one of the most impressive teams in college football to start the season. With big wins against Kansas State in Dublin and a win against their rival Iowa, the Cyclones find themselves ranked 14th. With all things going right for Iowa State, this week could prove to be its first let down spot. After a tight victory against an in-state rivalry, Iowa State will need to prove its attention to detail this week against Arkansas State. The Red Wolves have struggled defensively early this year, especially against the run, but this team can put up points offensively thanks to junior, dual-threat quarterback Raynor, who threw for over 2500 yards in both of his previous seasons under center for the Red Wolves.

Despite falling behind early last week, Arkansas State showed they can hang with top teams when they controlled possession for most of the 2nd quarter against Arkansas. Raynor even has an explosive receiver on the outside, Chauncy Cobb, who returned a 98-yard touchdown last week against Arkansas. Iowa State should still win this week, but I don’t think Arkansas State will go down easily on their home field. 

Iowa State vs Arkansas State prediction: Arkansas State +20.5 is available at the time of publishing. Playable at that number.

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