Kennesaw State Owls vs FIU Panthers Prediction, Odds and Picks for Today, 10/21/25

Kennesaw State heads to South Florida looking for its first win of the season in three tries on the road. Meanwhile, FIU welcomes the Owls looking for redemption after losing 27-26 in suburban Atlanta last season as a 9-point favorite. FIU outgained Kennesaw State by a 400-to-358 margin in total yardage, but the Owls had a fourth quarter comeback after entering the final quarter down 26-17.

FIU is flying high after dealing Western Kentucky its first conference loss last week in Bowling Green, winning 25-6 in emphatic fashion as a 10-point underdog. That snapped a 10-game losing streak on the road, which, technically should have ended against Kennesaw State, if not for the big comeback last November by KSU. The Owls have won four in a row, and they’ve covered three in a row, scoring 24 or more points in every game to date. Their only two losses are at Wake Forest, 10-9, on Aug. 29, and against No. 2 Indiana on Sept. 6, falling 56-9. The Owls have covered three in a row, too. Still, a trip to South Florida in the heat and humidity will be tough to overcome, as will a battle against a Panthers team which handily topped the previously first-place Hilltoppers in their place.

FIU Moneyline (+140) at time of publishing. Playable to +120.