Memphis Tigers vs Florida Atlantic Owls Prediction, Odds and Picks for Tomorrow, 09/27/25

The unbeaten Memphis Tigers hit the road for South Florida for the American Conference opener against the FAU Owls in Boca Raton, Fla. Memphis is brimming with confidence after picking up a thrilling 32-31 win over Arkansas last weekend as a 7-point underdog at the Simmons Bank Liberty Bowl. Memphis is not only 4-0 SU, but it is 4-0 ATS, too, and the Tigers have scored at least 28 points in all four games. The defense has been tough against non-Power 4 teams, too, allowing just 11.0 PPG in three games against Chattanooga, Georgia State and Troy.

FAU was throttled by Maryland to open, it won 56-14 against Florida A&M at home in Sept. 6, and it lost 38-28 to rival FIU on the road on Sept. 13 before a bye week. Against FBS teams, the Owls defense has been trampled for 38.5 PPG, and that’s bad news with the high-octane Memphis offense coming to town. FAU has been erratic on offense, and it just doesn’t have the horses to stick with the Tigers. Look for Memphis to pull away in the second half for a convincing conference victory in the American opener for both squads.

Memphis -14 (-110) at time of publishing. Playable to -16.