HomeCollege FootballCollege Football PredictionsMichigan State Spartans vs USC Trojans Prediction, Odds and Picks

Michigan State Spartans vs USC Trojans Prediction, Odds and Picks for Saturday, 09/20/25

Updated: 5:00 AM ET Sep 21, 2025

Los Angeles Memorial Coliseum FOX

3-0

Michigan State

11:00 PM ETSat Sep 20

3-0

USC

Joe Williams

Updated: 5:00 AM ET September 21, 2025

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