Michigan Wolverines vs Oklahoma Sooners Prediction, Odds and Picks for Today, 09/06/25

One of the most anticipated games on the college football Week 2 slate comes features a Big Ten vs SEC showdown, when the Michigan Wolverines take on the Oklahoma Sooners in a battle between two of the premier brands in the sport. Both of these teams have a lot to prove in this matchup, as the Sooners are coming off a dismal season in their first year in the SEC, while the Wolverines struggled mightily on offense in 2024 following a season in which they were crowned National Champions. One of these teams will take a massive step forward on the road to redemption in 2025, and I’m of the belief that the hosts will emerge victorious on Saturday.

It’s easy to buy the upside with Michigan as an underdog in this spot. After all, the Wolverines were a total disaster on offense a season ago, and the insertion of 5-star true freshman quarterback Bryce Underwood is a move that instantly raises the ceiling of this unit a ton. However, as I mentioned in my Big Ten season preview, Underwood is still very unproven and I think there will be some clear growing pains this season, especially considering the caliber of defense he’ll be facing in this one. Given the fact that Underwood is making his first ever road start in an extremely difficult environment, Michigan should look to lean on its ground game early and often. The problem for the Wolverines is they will likely struggle to move the ball against a ferocious Oklahoma defense that ranks 3rd in rushing success rate allowed and 13th in points per drive (CFB-Graphs). It still remains to be seen if the Wolverines passing game can take a step forward this season, and I don’t foresee this as being the game where Underwood and these unproven wide receivers break out.

On the other side of the ball, Michigan is replacing some massive pieces on defense, as Mason Graham, Kenneth Grant and Will Johnson are off to the NFL. Those losses really showed in the Wolverines’ season opener against New Mexico, as the Lobos were surprisingly able to keep that game close, easily covering the massive spread in the Big House. In steps Oklahoma’s new-look offense, with quarterback John Mateer bringing along offensive coordinator Ben Arbuckle from Washington State. The Sooners kept things very vanilla in last week’s win over Illinois State, and I’d expect Oklahoma to have a few tricks up its sleeve in this pivotal early-season matchup. Ultimately, my handicap is a bit more about fading Michigan than backing Oklahoma, but I’m still confident in Mateer and the Sooners defense to rise to the challenge and win by margin at home.

Michigan vs Oklahoma prediction: Oklahoma -4.5 available at time of publishing. Playable at that number.

If you’re looking for a new sportsbook for the football season, we recommend checking out Fanatics Sportsbook. New users can get up to $100 back in FanCash EVERY GAMEDAY UNTIL OCTOBER if their football bet loses! Join Fanatics Sportsbook, where you can bet on our Michigan vs Oklahoma predictions.

As I mentioned in my spread prediction, the Michigan offense is not one that I am looking to back at the moment, particularly when you factor in that this is Underwood’s first collegiate start on the road. The true freshman is likely going to be the next great Michigan quarterback, but he doesn’t have a great group of weapons surrounding him at the skill positions, and the Oklahoma defensive front will certainly be one of the best units he faces all season. What the Wolverines have going for them is another solid defense, despite the fact that they lost a number of high-level players to the NFL. It won’t be as good as last season’s unit, but Michigan is still capable of slowing down Mateer in what will be his first start against a defense of this caliber. This has all the makings of a game where both teams try to establish the run early and lean on their defenses in hopes for forcing a pivotal turnover to swing the game their way.

Michigan vs Oklahoma prediction: Under 45.5 available at time of publishing. Playable to 45.

Now you can bet any of our Michigan vs Oklahoma predictions at FanDuel Sportsbook, which has a great new-customer offer to take advantage of. If you sign up for FanDuel right now, you earn a welcome bonus worth up to $300 if your first $5 bet wins! Use this link 🔗 to join FanDuel right now and learn more.