Mississippi State Bulldogs vs Missouri Tigers Prediction, Odds and Picks for Today, 11/15/25

SEC play rolls along on Saturday night when the Mississippi State Bulldogs head to Columbia, Missouri to take on the Tigers. Both the Bulldogs and the Tigers come into this game following 20+ point losses last week, as MSU lost 41-21 at home against Georgia while Missouri lost at home to Texas A&M 38-17. Neither loss is one that either team should hang its head over, but the respective favorites cruised to wins and covers in those games largely because Mississippi State and Missouri were ineffective offensively. 

The quarterback situation is murky on both sidelines in this matchup. Missouri’s Beau Pribula is out for at least the regular season, while Mississippi State’s Blake Shapen was limited with an injury against Georgia and is questionable for this upcoming weekend. As such, a pair of freshmen have been thrust into significant roles. Missouri’s Matt Zollers was okay against Vanderbilt but looked overmatched against Texas A&M last week, and he doesn’t have the same rushing upside as Pribula. Meanwhile, Mississippi State’s Kamario Taylor is more of a runner than a passer. 

With the uncertain quarterback situation on both sides, it’s tough to get a grasp on this game. However, I think we can expect both teams to have a run-heavy approach – especially if Shapen misses the game – which would mean a running clock for a majority of this contest. Hence, I’m going to lean to the under here. Look for Mississippi State’s Fluff Bothwell and Missouri’s Ahmad Hardy to have significant roles in what could be an ugly offensive showing from both teams.

Mississippi State vs Missouri prediction: Under 51.5 (-110) at the time of publishing. Playable to 51. 

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