Missouri State Bears vs Middle Tennessee Blue Raiders Prediction, Odds and Picks for Today, 10/08/25

Missouri State hits the road for their first conference road game. The Bears have alternated loss and wins in the first 5 games, while going 1-1 straight up (SU) and against the spread (ATS) in its first couple of road games. The first game was a 73-13 loss at USC, where the Bears failed to come close to the number as a 35.5-point underdog, while winning outright as a 7-point underdog in a 21-20 win at Marshall on Sept. 6. The Bears are 3-1 ATS in the past 4 games, while cashing the under in each of those outings. The Bears have scored 22 or fewer points in 4 of 5 games, while allowing 28 or fewer points in the past 4 contests since that 73-point debacle against the Trojans.

Middle Tennessee started the season with a 34-14 loss at home against FCS Austin Peay despite being a 15-point favorite, and the Blue Raiders are a dismal 1-4 ATS on the year. The only exception was a stunning 14-13 road win at Nevada as a 9-point underdog as the Under cashed. The Blue Raiders are 0-2 SU/ATS in a pair of home games, and it suffered a 24-16 loss at Kennesaw State in the league opener last time out on Sept. 27 as the under came through. Take Missouri State laying the points for your best bet on Wednesday.

Missouri State vs Middle Tennessee prediction: Missouri State -2.5 (-110) available at time of publishing. Playable to 3.

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